207985-74-8Relevant academic research and scientific papers
Organocatalytic asymmetric oxy-Michael addition to a γ-hydroxy- α,β-unsaturated thioester via hemiacetal intermediates
Okamura, Takaaki,Asano, Keisuke,Matsubara, Seijiro
supporting information; experimental part, p. 5076 - 5078 (2012/07/02)
We report an asymmetric oxy-Michael addition to a γ-hydroxy-α, β-unsaturated thioester via hemiacetal intermediates in the presence of Cinchona-alkaloid-thiourea-based bifunctional organocatalysts. This method provides a novel enantioselective route to β-hydroxy carboxyl compounds, which in turn can be used to synthesize valuable chiral building blocks.
METHOD FOR PREPARING (S)-3-HYDROXY-GAMMA-BUTYROLACTONE USING HYDROLASE
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Page/Page column 6-7, (2008/06/13)
The present invention relates to a method for preparing S-HGB ((S)-3-hydroxy-γ-butyrolactone) using hydrolase, and more particularly to a method for preparing S-HGB in a high purity by hydrolyzing S-BBL ((S)-β-benzoyloxy-γ-butyrolactone) in the presence of hydrolase. According to the present invention, the S-HGB having an optical purity can be obtained in a high yield under simple process conditions without requiring reaction conditions of high pressure and high temperature or complex operation conditions by hydrolyzing S-BBL with hydrolase.
Synthesis of 3′-O-phosphonomethyl nucleosides with an adenine base moiety
Vi?a, Dolores,Wu, Tongfei,Renders, Marleen,Laflamme, Geneviève,Herdewijn, Piet
, p. 2634 - 2646 (2007/10/03)
A synthetic scheme has been developed for the synthesis of 2′-deoxythreose phosphonate nucleosides from β-hydroxy-γ-butyrolactone and of 2′-azido erythrose phosphonate nucleosides from dihydroxydihydrofuran-1-one. In addition several α-l-arabinofuranose p
PHOSPONATE NUCLEOSIDES USEFUL AS ACTIVE INGREDIENTS IN PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS, AND INTERMEDIATES FOR THEIR PRODUCTION
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Page/Page column 98, (2010/02/14)
The present invention relates to novel phosponate nucleosides, more specifically to novel phosponalkoxy substituted nucleosides. The invention further relates to compounds having HIV (Human Immunodeficiency Virus) replication inhibiting properties and to
Beta-substituted-gamma-butyrolactones and a process for preparation thereof
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Page 6, (2008/06/13)
The present invention is related to a process for the preparation of (S)- or (R)-β-substituted-γ-butyrolactones or a racemic mixture thereof. β-substituted-γ-succinic anhydrides are converted by zinc borohydride in a compatible solvent selected from tetra
