208036-26-4

Upstream product

• 1663-39-4 tert-Butyl acrylate 
• 1122-91-4 4-bromo-benzaldehyde 
• 141-32-2 acrylic acid n-butyl ester 
• 88373-27-7 4-tri-n-butylstannylbenzaldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 87199-17-5 4-formylphenylboronic acid, 

Downstream Products

• 274903-31-0 3-[4-(2-[4-((E)-2-tert-butoxycarbonyl-vinyl)phenyl]-5-{4-[(E)-2-(3-phenylpropylcarbamoyl)vinyl]phenyl}-1H-imidazol-4-yl)phenyl]-4,5-dihydro-isoxazole-5-carboxylic acid tert-butyl ester 
• 425431-82-9 (3R,αS)-tert-butyl 3-(N-benzyl-N-α-methylbenzylamino)-3-(4-formyl-phenyl)-propanoate 
• 913237-70-4 (E)-tert-butyl 3-(4-(hydroxymethyl)phenyl)acrylate 
• 1109237-15-1 C₄₁H₃₄N₄O₆ 
• 1109237-07-1 C₄₀H₃₄N₄O₅ 
• 1109237-11-7 C₂₆H₂₇N₃O₆ 
• 1109236-81-8 C₂₂H₂₀N₄O₆ 
• 1109236-72-7 C₂₁H₂₀N₄O₅ 
• 1109236-96-5 C₂₅H₂₇N₃O₅ 
• 1109237-13-9 C₂₂H₁₉N₃O₆ 
• 1109236-93-2 (E)-tert-butyl 3-(4-(aminomethyl)phenyl)acrylate hydrochloride 
• 1109237-01-5 C₂₁H₁₉N₃O₅ 
• 425431-80-7 (3R,αS,3'S,α'R)-di-tert-butyl benzene-1,4-bis[3-(N-benzyl-N-α-methylbenzylamino)propanoate] 
• 425431-81-8 (3R,αS,E)-tert-butyl 3-(N-benzyl-N-α-methylbenzylamino)-3-[4-(3-tert-butoxy-3-oxoprop-1-enyl)phenyl]propanoate 

Relevant academic research and scientific papers

Suzuki-Miyaura cross-coupling and Heck-Mizoroki reactions catalysed by palladium on carbon nanofibres

Platelet, tubular and herringbone carbon nanofibres were doped with Pd under various conditions. The catalysts were analysed for their Pd-content and as to the size distribution of the Pd particles. The Pd-doped carbon nanofibres were screened for their c

Pd(II) complexes of a sterically bulky, benzannulated N-heterocyclic carbene and their catalytic activities in the Mizoroki-Heck reaction

The bis(N,N′-diisopropylbenzimidazolin-2-ylidene)Pd(II) complexes trans-[PdBr2(iPr2-bimy)2] (trans-1) and trans-[PdI2(iPr2-bimy)2] (trans-2) have been prepared in good

A Bis (BICAAC) Palladium(II) Complex: Synthesis and Implementation as Catalyst in Heck-Mizoroki and Suzuki-Miyaura Cross Coupling Reactions

Carbenes are one of the most appealing, well-explored, and exciting ligands in modern chemistry due to their tunable stereoelectronic properties and a wide area of applications. A palladium complex (BICAAC)2PdCl2 with a recently discovered cyclic (alkyl)(amino)carbene having bicyclo[2.2.2] octane skeleton (BICAAC) was synthesized and characterized. The enhanced σ-donating and π-accepting ability of this carbene lend a hand to form a robust Pd-carbene bond, which allowed us to probe its reactivity as a precatalyst in Heck-Mizoroki and Suzuki-Miyaura cross-coupling reactions with low catalyst loading in open-air conditions. The diverse range of substrates was explored for both the cross-coupling reactions. To get a better understanding of the catalytic reactions, several analytical techniques such as field-emission scanning electron microscopy, high-resolution transmission electron microscopy, and powder X-ray diffraction were employed in a conclusive manner.

Palladium-Based Catalysts Supported by Unsymmetrical XYC–1 Type Pincer Ligands: C5 Arylation of Imidazoles and Synthesis of Octinoxate Utilizing the Mizoroki–Heck Reaction

A series of new unsymmetrical (XYC–1 type) palladacycles (C1–C4) were designed and synthesized with simple anchoring ligands L1–4H (L1H = 2-((2-(4-methoxybenzylidene)-1-phenylhydrazinyl)methyl)pyridine, L2H = N,N-dimethyl-4-((2-phenyl-2-(pyridin-2-ylmethyl)hydrazono)methyl)aniline, L3H = N,N-diethyl-4-((2-phenyl-2-(pyridin-2-ylmethyl)hydrazono)methyl) aniline and L4H = 4-(4-((2-phenyl-2-(pyridin-2-ylmethyl)hydrazono) methyl)phenyl)morpholine H = dissociable proton). Molecular structure of catalysts (C1–C4) were further established by single X-ray crystallographic studies. The catalytic performance of palladacycles (C1–C4) was explored with the direct Csp2–H arylation of imidazoles with aryl halide derivatives. These palladacycles were also applied for investigating of Mizoroki–Heck reactions with aryl halides and acrylate derivatives. During catalytic cycle in situ generated Pd(0) nanoparticles were characterized by XPS, SEM and TEM analysis and possible reaction pathways were proposed. The catalyst was employed as a pre-catalyst for the gram-scale synthesis of octinoxate, which is utilized as a UV-B sunscreen agent.

Monodentate phosphorus-coordinated palladium(II) complexes as new catalyst for Mizoroki-Heck reaction of aryl halides with electron-deficient olefins

Four novel palladium(II) complexes coordinated by phosphorus atoms from both 3,5-disubstituted-1H-1,2,4-diazaphospholes in monodentate fashion were developed as efficient catalyst for the Mizoroki-Heck reaction of aryl halides with electron-deficient olefins. The coupling reaction of aryl halide bearig different functional groups with olefin derivatives took place and the corresponding products were isolated in good to excellent yields under optimal conditions. The procedure exhibits good functional group tolerance and wide substrate scope. This Mizoroki-Heck reaction was further achieved using Pd(OAc)2 and 3,5-di-isopropyl-1H-1,2,4-diazaphospholes as combined catalyst, which provide the convenient and alternative method in organic synthesis

Pd doped SiO2 nanoparticles: An efficient recyclable catalyst for Suzuki, Heck and Sonogashira reactions

Palladium doped silica (Pd/SiO2) mesoporous material was synthesized via the sol-gel route using the P123 triblock copolymer as a structure directing agent. Pd/SiO2 was efficiently used as a catalyst for Suzuki, Heck and Sonogashira reactions under microwave irradiation. The catalyst exhibited high activity for all the coupling reactions and can be recycled nine times without a significant loss in its catalytic activity. This journal is the Partner Organisations 2014.

Ligand-free PdCl2-catalyzed heck reaction of arylboronic acids and olefins under reusable TBAB/H2O conditions

A novel method was developed for Heck reaction of olefins and arylboronic acids using a ligand-free PdCl2 catalyst to afford the coupling products with excellent regio- and stereoselectivity. It is noteworthy that the PdCl2/CuSO4/K2CO3/TBAB/H 2O system can be recovered and used for three cycles directly. Georg Thieme Verlag Stuttgart, New York.

Palladium-catalyzed heck reaction of aryl chlorides under mild conditions promoted by organic ionic bases

An efficient Pd-catalyzed Heck reaction of aryl chlorides with olefins under mild conditions is described. High yields of products were achieved with n-Bu4N+OAc- as base. Significantly, the temperature of the Heck reaction of diverse nonactivated aryl chlorides can be lowered to 80 °C. The new reaction system can also tolerate a wider range of olefins.

Ce0.98Pd0.02O2-δ: Recyclable, ligand free palladium(II) catalyst for Heck reaction

Palladium substituted in cerium dioxide in the form of a solid solution, Ce0.98Pd0.02O1.98 is a new heterogeneous catalyst which exhibits high activity and 100% trans-selectivity for the Heck reactions of aryl bromides including heteroaryls with olefins. The catalytic reactions work without any ligand. Nanocrystalline Ce0.98Pd 0.02O1.98 is prepared by solution combustion method and Pd is in +2 state. The catalyst can be separated, recovered and reused without significant loss in activity. Indian Academy of Sciences.

CATIONIC PALLADIUM COMPLEXES COMPRISING DIAMINO CARBENE LIGANDS AND THEIR USE IN CATALYSIS

Cationic palladium catalysts comprising diamino carbene ligands, wherein the catalysts are of the formula [Pd(X)q(LBX)t(DC)]r+[Ym-]p or [Pd(X)q(LB)n(LBX)t(DC)]2a+[V-]u[Z2-]y, wherein DC is a diamino carbene ligand, X is an anionic ligand, LBX is a combined anionic and neutral ligand, and Y, V, and Z are non-coordinating anions. The compounds are useful in catalytic reactions, including cross-coupling reactions and hydroamination reactions. In particular, the catalysts are used in the following reactions: Suzuki-Miyaura coupling, Kumada coupling, Negishi coupling, Sonogashira coupling, Hartwig-Buchwald amination, and Heck-Mizoroki coupling.