20815-42-3Relevant academic research and scientific papers
Rhodium-catalyzed, three-component reaction of diazo compounds with amines and azodicarboxylates
Huang, Haoxi,Wang, Yuanhua,Chen, Zhiyong,Hu, Wenhao
, p. 531 - 534 (2005)
A novel, three-component C-N bond forming reaction is described. Reaction of diazo compounds with both azodicarboxylates and arylamines in the presence of dirhodium acetate catalyst gives good yields of the corresponding aminal with high selectivity and, in most cases, N-H insertion side products were suppressed. This is the first example of a C-N bond formation from the addition of ammonium ylides to azodicarboxylates.
Rhodium-Catalyzed C=N Bond Formation through a Rebound Hydrolysis Mechanism and Application in β-Lactam Synthesis
Chen, Long,Zhang, Linxing,Shao, Ying,Xu, Guangyang,Zhang, Xinhao,Tang, Shengbiao,Sun, Jiangtao
supporting information, p. 4124 - 4127 (2019/06/08)
A rhodium-catalyzed reaction of N-hydroxyanilines with diazo compounds to produce α-imino esters was developed. Distinct from the commonly accepted 1,2-H transfer for normal X-H insertion reactions, density functional theory calculations indicate that this transformation proceeds via a novel rebound hydrolysis mechanism. Furthermore, a three-component reaction was explored to synthesize highly functionalized β-lactams in good yields and diastereoselectivities.
DERIVATIVES OF IMINOMALONIC ESTER
Prosyanik, A. V.,Fedoseenko, D. V.,Markov, V. I.
, p. 1494 - 1503 (2007/10/02)
The synthesis of (alkylimino)malonic esters was realized by the reaction of alkylamines with mesoxalic or dibromomalonic ester. (Halogenimino)malonic esters were obtained for the first time by the reaction of aminomalonic ester with tert-butyl hypochlorite or sodium hypobromite.A new method was developed for the synthesis of (acylimino)malonic esters by the successive bromination and dehydrobromination of (acylamino)malonic esters.The addition of various nucleophiles (water, amines, formamide) at the C=N bond of (acylimino)malonic esters was studied.
ARYLIMINOMALONIC ESTERS
Markov, V. I.,Prosyanik, A. V.,Fedoseenko, D. V.,Loban', S. V.,Starovoitov, V. V.
, p. 2209 - 2215 (2007/10/02)
The condensation of nitrosobenzene with malonis esters is the best method for the production of dialkyl phenyliminomalonates, whereas the thermolysis of symmetrical and unsymmetrical di(arylamino)malonic esters is a good method for the synthesis of substituted dialkyl aryliminomalonates.
