20826-48-6Relevant articles and documents
Effect of ligand and bridge substitution on chiral recognition of 1-phenylethylammonium cation by an anionic binuclear Ni(II) complex
Das, Chandani Rani,Dutta, Tanmay,Ray, Manabendra
, p. 367 - 376 (2019)
Chiral recognition is an important phenomenon. Identifying factors those influences recognition and resolution have significance in multiple areas. Earlier, we had reported recognition and resolution (30% ee) of 1-phenylethylammonium cation using an anion
A dual-catalysis anion-binding approach to the kinetic resolution of amines: Insights into the mechanism via a combined experimental and computational study
Mittal, Nisha,Lippert, Katharina M.,De, Chandra Kanta,Klauber, Eric G.,Emge, Thomas J.,Schreiner, Peter R.,Seidel, Daniel
, p. 5748 - 5758 (2015)
Racemic benzylic amines undergo kinetic resolution via benzoylation with benzoic anhydride in the presence of a dual catalyst system consisting of a readily available amide-thiourea catalyst and 4-dimethylaminopyridine (DMAP). An evaluation of various exp
Three-Component Iminolactonization Reaction via Bifunctionalization of Olefins Using Molecular Iodine and Visible Light
Itoh, Akichika,Maejima, Saki,Yamaguchi, Eiji
, p. 10709 - 10718 (2020)
A novel three-component ?-iminolactonization reaction was developed, which relied on the C-C/C-O bond-forming bifunctionalization of olefins using molecular iodine and visible light. This strategy did not require any (heavy) metal reagents for double-bond activation because molecular iodine acted as a rare-metal-alternative reagent through visible light irradiation. In addition, the preactivation of amines and other substrates is not required. The mechanistic investigation revealed that the generated iodine radicals under visible light irradiation reacted with alkenes to form a highly reactive intermediate; then, the three-component reaction of diiodide, malonate, and amine furnished iminolactone. Of note, the developed reaction is simple and realized the diversity-oriented synthesis innovative methodology of ?-iminolactone derivatives in drug discovery chemistry.
Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous-Flow
Chen, Xiangyang,Houk, Kendall N.,Mo, Jia-Nan,Su, Junqi,Umanzor, Alexander,Zhang, Zheng,Zhao, Jiannan
supporting information, (2022/01/06)
Phosphine-mediated deoxygenative nucleophilic substitutions, such as the Mitsunobu reaction, are of great importance in organic synthesis. However, the conventional protocols require stoichiometric oxidants to trigger the formation of the oxyphosphonium i
Nickel-Catalyzed Asymmetric Synthesis of α-Arylbenzamides
Cuesta-Galisteo, Sergio,Sch?rgenhumer, Johannes,Wei, Xiaofeng,Merino, Estíbaliz,Nevado, Cristina
supporting information, p. 1605 - 1609 (2020/12/01)
A nickel-catalyzed asymmetric reductive hydroarylation of vinyl amides to produce enantioenriched α-arylbenzamides is reported. The use of a chiral bisimidazoline (BIm) ligand, in combination with diethoxymethylsilane and aryl halides, enables the regioselective introduction of aryl groups to the internal position of the olefin, forging a new stereogenic center α to the N atom. The use of neutral reagents and mild reaction conditions provides simple access to pharmacologically relevant motifs present in anticancer, SARS-CoV PLpro inhibitors, and KCNQ channel openers.
