2084-28-8

Basic information

• Product Name: (trans-4-Carboethoxycyclohexyl)aMine Hydrochloride
• Synonyms: (trans-4-Carboethoxycyclohexyl)aMine Hydrochloride;Ethyl trans-4-AMinocyclohexanecarboxylate Hydrochloride;trans-4-AMinocyclohexanecarboxylic Acid Ethyl Ester Hydrochloride;Trans-ethyl 4-aMinocyclohexanecarboxylate hydrochloride;Ethyl trans-4-Amino-cyclohexanecarboxylate HCl;TRANS ETHYL 4-AMINOCYCLOHEXANECARBOXYLATE HCL
• CAS NO: 2084-28-8
• Molecular Formula: C9H18ClNO2
• Molecular Weight: 207.69772
• Product Categories: Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 2084-28-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 153 °C
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (trans-4-Carboethoxycyclohexyl)aMine Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (trans-4-Carboethoxycyclohexyl)aMine Hydrochloride(2084-28-8)
• EPA Substance Registry System: (trans-4-Carboethoxycyclohexyl)aMine Hydrochloride(2084-28-8)

Safety Data

• Hazardous Substances Data: 2084-28-8(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 2084-28-8 differently. You can refer to the following data:
1. Ethyl trans-4-Aminocyclohexanecarboxylate is a cyclohexane carboxylate amino isomer. Ethyl trans-4-Aminocyclohexanecarboxylate is used in the synthesis of trans-4-(6-substituted-9-purinyl)cyclohexylcarbinols as inhibitors of adenosine deaminase.
2. trans-Ethyl 4-aminocyclohexanecarboxylate hydrochloride is a cyclohexane carboxylate amino isomer. Ethyl trans-4-Aminocyclohexanecarboxylate is used in the synthesis of trans-4-(6-substituted-9-purinyl)cyclohexylcarbinols as inhibitors of adenosine deaminase.

InChI:InChI=1/C9H17NO2.ClH/c1-2-12-9(11)7-3-5-8(10)6-4-7;/h7-8H,2-6,10H2,1H3;1H/t7-,8-;

Upstream product

• 619-82-9 trans-hexahydroterephthalic acid 
• 19145-96-1 diethyl cyclohexane-trans-1,4-dicarboxylate 
• 64-17-5 ethanol 
• 3685-23-2 cis-4-aminocyclohexane-1-carboxylic acid 
• 94-09-7 p-aminoethylbenzoate 
• 51498-33-0 ethyl 4-amino-1-cyclohexanecarboxylate 
• 27960-59-4 trans-4-aminocyclohexanecarboxylic acid hydrochloric acid 
• 1776-53-0 trans-4-aminocyclohexanecarboxylic acid 
• 1678-68-8 ethyl trans-4-aminocyclohexanecarboxylate 

Relevant articles and documents

COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 POLYPEPTIDES

The present disclosure relates to bifunctional compounds, which find utility as modulators of Interleukin-1 Receptor-Associated Kinase 4 (IRAK-4); the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hppel-Lindau, cereblon, ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

METHOD FOR PRODUCING DICARBOXYLIC ACID COMPOUND

It is an object of the present invention to provide an excellent method for producing an excellent therapeutic agent. The solution of the present invention is as shown in the following scheme: wherein R1 represents a C1-C6 alkyl group, R2 represents a C1-C6 alkyl group, and R3 represents a C1-C6 alkyl group.

PYRIDIN-2(1H)-ONE DERIVATIVES AS JAK INHIBITORS

New pyridin-2(1H)-one derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).