208453-06-9

Upstream product

• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 
• 75-08-1 ethanethiol 

Downstream Products

• 15540-09-7 1-(4-methoxy-phenyl)-5-methyl-hexan-3-one 
• 1669-49-4 3-(4-methoxyphenyl)-1-phenylpropan-1-one 
• 100765-45-5 5-(p-methoxyphenyl)-2-methyl-3-pentanone 
• 683226-20-2 3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-phenyl)-2-methyl-pentanethioic acid S-dodecyl ester 
• 683226-19-9 (S)-4-Benzyl-3-[(2S,3R)-3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-phenyl)-2-methyl-pentanoyl]-oxazolidin-2-one 
• 683226-18-8 (S)-4-Benzyl-3-[(2S,3R)-3-hydroxy-5-(4-methoxy-phenyl)-2-methyl-pentanoyl]-oxazolidin-2-one 
• 5440-80-2 1-(4-methoxyphenyl)-3-oxo-pentane 

Relevant academic research and scientific papers

Nickel-Catalyzed Coupling of Arylzinc Halides with Thioesters

The Pd-catalyzed Fukuyama reaction of thioesters with organozinc reagents is a mild, functional-group-tolerant method for acylation chemistry. Its Ni-catalyzed variant might be a sustainable alternative to expensive catalytic Pd sources. We investigated the reaction of S-ethyl thioesters with aryl zinc halides with hetero- and homotopic Ni precatalysts and several ligands. The results show that both homo- and heterotopic species may contribute to catalysis. The substrate scope using an operationally homogeneous defined Ni complex was established. Acyl radicals are postulated as short-lived intermediates.

Synthesis of acylsilanes by palladium-catalyzed cross-coupling reaction of thiol esters and silylzinc chlorides

An acylsilane synthesis by a Pd-catalyzed cross-coupling reaction of thiol esters and silylzinc chlorides was developed. S-Phenyl thiol esters with a variety of functional groups were converted to corresponding acylsilanes.

A novel ketone synthesis by a palladium-catalyzed reaction of thiol esters and organozinc reagents

A variety of ketones have been prepared by a palladium-catalyzed reaction of ethanethiol esters with organozinc reagents. Various functional groups, including esters, ketones, aromatic halides and aldehydes, tolerate the reaction conditions. The reaction can also be applied to the synthesis of α-amino ketones using the corresponding L-α-amino thiol esters without racemization.