20849-75-6

Usage

Chlorinated derivative

3-nitrostyrene

Usage

Building block in organic synthesis, production of pharmaceuticals, agrochemicals, and other fine chemicals, precursor in the synthesis of dyes and pigments

Physical properties

Colorless to pale yellow liquid, molecular weight of 197.61 g/mol, melting point of -10°C

Importance

Intermediate in the manufacturing of various industrial and commercial products

Upstream product

• 74-85-1 ethene 
• 2865-17-0 m-nitrophenylmercury(II) chloride 
• 52022-77-2 2-(3-nitrophenyl)ethanol 
• 1877-73-2 3-nitro-benzeneacetic acid 
• 10268-12-9 methyl 3-nitrophenylacetate 

Downstream Products

• 925920-57-6 C₁₂H₁₆N₂O₃ 
• 1026254-48-7 2-{1-[2-(3-Nitro-phenyl)-ethyl]-piperidin-4-yl}-1H-benzoimidazole 

Relevant academic research and scientific papers

SUBSTITUTED N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3- DIOXYGENASE

The invention provides modulators of indoleamine 2,3-dioxygenase (IDO1) and their use in the prophylaxis and/or treatment of IDO1-mediated diseases. Specifically, the present invention provides compounds according to Formula (I) an enantiomer, diastereomer, tautomer or pharmaceutically acceptable salt thereof.

IMIDAZO-THIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Compounds of formula I that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula I and therapeutically acceptable salts, prodrugs and salts of prodrugs thereof, wherein X is CH or N; A1 is R1, OR1. NHR1, N(R1)2, NHC(O)R1, NHC(O)NHR1, NHC(O)N(R1)2, NHC(O)OR1, C(O)NHR1, C(O)N(R1)2, C=NOR1, or C(NH2)NOC(O)R1;