20849-77-8

Basic information

• Product Name: 2-Butanone, 3-chloro-4-phenyl-
• CAS NO: 20849-77-8
• Molecular Formula: C10H11ClO
• Molecular Weight: 182.65
• Mol File: 20849-77-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-Butanone, 3-chloro-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butanone, 3-chloro-4-phenyl-(20849-77-8)
• EPA Substance Registry System: 2-Butanone, 3-chloro-4-phenyl-(20849-77-8)

Safety Data

• Hazardous Substances Data: 20849-77-8(Hazardous Substances Data)

Upstream product

• 2550-26-7 4-Phenyl-2-butanone 
• 53973-14-1 (Z)-3-chloro-4-phenyl-3-buten-2-one 
• 52755-38-1 1-phenyl-2-buten-1-ol 
• 2344-70-9 1-phenyl-3-butanol 
• 36004-04-3 ethyl (E)-1-phenylbut-1-en-3-ol 
• 1896-62-4 (E)-benzalacetone 
• 87769-52-6 tert-butyl 2-benzylacetoacetate 
• 620-79-1 Ethyl 2-benzylacetoacetate 
• 78-94-4 methyl vinyl ketone 
• 100-56-1 phenylmercury(II) chloride 
• 1560-06-1 1-phenyl-2-butene 
• 24251-72-7 (1-Benzyl-1-chloro-2-oxo-propyl)-triphenyl-phosphonium; chloride 
• 130200-27-0 ethyl 2-benzyl-2-chloro-3-oxobutanoate 

Downstream Products

• 65304-56-5 3-phenoxy-4-phenyl-butan-2-one 
• 1896-62-4 (E)-benzalacetone 
• 1821-12-1 4-Phenylbutyric acid 
• 1311386-54-5 4-chloro-3-methyl-1,5-diphenylpent-1-yn-3-ol 
• 65248-93-3 5-benzyl-4-methyl-2-aminothiazole 

Relevant articles and documents

Synthesis and reactivity of α-sulfenyl-β-chloroenones, including oxidation and Stille cross-coupling to form chalcone derivatives

The synthesis of a range of novel α-sulfenyl-β-chloroenones from the corresponding α-sulfenylketones, via a NCS mediated chlorination cascade, is described. The scope of the reaction has been investigated and compounds bearing alkyl- and arylthio substituents have been synthesised. In most instances, the Z α-sulfenyl-β-chloroenones were formed as the major products, while variation of the substituent at the β-carbon position led to an alteration in stereoselectivity. Stille cross-coupling with the Z α-sulfenyl-β-chloroenones led to selective formation of Z sulfenyl chalcones, while the E α-sulfenyl-β-chloroenones did not react under the same conditions. Oxidation of the Z α-sulfenyl-β-chloroenones was followed by isomerisation, leading to the E α-sulfinyl-β-chloroenones. Stille cross-coupling with the E α-sulfinyl-β-chloroenones produced the E sulfinyl chalcones. Either the E or Z sulfinyl chalcones can be obtained by altering the sequence of oxidation and Stille cross-coupling.

Acid- and iridium-catalyzed tandem 1,3-transposition/3,1-hydrogen shift/chlorination of allylic alcohols

A method for the selective synthesis of α-chlorocarbonyls from allylic alcohols is presented. The reaction occurs through an acid- and iridium-catalyzed tandem process that combines a 1,3-transposition, a 3,1-hydrogen shift, and a chlorination process, and can be applied to a wide range of α-aromatic and heteroaromatic secondary allylic alcohols. Saturated non-chlorinated ketones or other side-products derived from overchlorination were not detected.

Enhancements of enantio and diastereoselectivities in reduction of (Z)-3-halo-4-phenyl-3-buten-2-one mediated by microorganisms in ionic liquid/water biphasic system

Reductions of (Z)-C6H5CHCXC(O)CH3 (X = Cl, Br) mediated by Saccharomyces cerevisiae, Candida albicans, Rhodotorula glutinis, Geotrichum candidum and Micrococcus luteus gave the corresponding halohydrins through consecutive