20850-05-9Relevant articles and documents
Hydroxyl Radicals via Collision-Induced Dissociation of Trimethylammonium Benzyl Alcohols
Moore, Peter W.,Hooker, Jordan P.,Zavras, Athanasios,Khairallah, George N.,Krenske, Elizabeth H.,Bernhardt, Paul V.,Quach, Gina,Moore, Evan G.,O'Hair, Richard A. J.,Williams, Craig M.
, p. 397 - 406 (2017)
The hydroxyl radical is a well known reactive oxygen species important for interstellar, atmospheric, and combustion chemistry in addition to multiple biochemical processes. Although there are many methods to generate the hydroxyl radical, most of these are inorganic based, with only a few originating from organic precursor molecules. Reported herein is the observation that trimethylammonium benzyl alcohols and their corresponding deuterated isotopologues act as a good source of hydroxyl and deuteroxyl radicals in the gas-phase under collision-induced dissociation (CID) conditions. Attempts to replicate this chemistry in the condensed phase are described.
Homogeneous Hydrogenation with a Cobalt/Tetraphosphine Catalyst: A Superior Hydride Donor for Polar Double Bonds and N-Heteroarenes
Duan, Ya-Nan,Du, Xiaoyong,Cui, Zhikai,Zeng, Yiqun,Liu, Yufeng,Yang, Tilong,Wen, Jialin,Zhang, Xumu
supporting information, p. 20424 - 20433 (2019/12/27)
The development of catalysts based on earth abundant metals in place of noble metals is becoming a central topic of catalysis. We herein report a cobalt/tetraphosphine complex-catalyzed homogeneous hydrogenation of polar unsaturated compounds using an air- and moisture-stable and scalable precatalyst. By activation with potassium hydroxide, this cobalt system shows both high efficiency (up to 24 000 TON and 12 000 h-1 TOF) and excellent chemoselectivities with various aldehydes, ketones, imines, and even N-heteroarenes. The preference for 1,2-reduction over 1,4-reduction makes this method an efficient way to prepare allylic alcohols and amines. Meanwhile, efficient hydrogenation of the challenging N-heteroarenes is also furnished with excellent functional group tolerance. Mechanistic studies and control experiments demonstrated that a CoIH complex functions as a strong hydride donor in the catalytic cycle. Each cobalt intermediate on the catalytic cycle was characterized, and a plausible outer-sphere mechanism was proposed. Noteworthy, external inorganic base plays multiple roles in this reaction and functions in almost every step of the catalytic cycle.
Preparation method of alpha,beta-unsaturated alcohol and/or alpha,beta-saturated alcohol
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Paragraph 0066-0071, (2019/08/20)
The invention belongs to the technical field of pharmaceutical chemical synthesis, and discloses a preparation method of alpha,beta-unsaturated alcohol and/or alpha,beta-saturated alcohol. The preparation method comprises the following steps: using alpha,beta-unsaturated aldehyde as a raw material and iridium as a catalyst, adding a solvent and a hydrogen source, stirring the obtained solution fora reaction in an air atmosphere at 25-100 DEG C, performing cooling after completion of the reaction, performing extraction on the obtained reaction solution by using ethyl acetate, removing the solvent under reduced pressure so as to obtain a crude product, and performing purification through column chromatography so as to obtain the alpha,beta-unsaturated alcohol and/or alpha,beta-saturated alcohol. The method with high chemical selectivity is adopted to synthesize the alpha,beta-unsaturated alcohol and alpha,beta-saturated alcohol, the synthesis method is simple and easy, has mild reactionconditions, wide adaptability to the substrate, a high product yield and good industrial application prospects.
