63511-96-6Relevant academic research and scientific papers
SYNTHESIS OF A TRIAD MOLECULAR SYSTEM CONTAINING THE PHOTOSENSITIZER MESOPORPHYRIN II AND A SECONDARY ELECTRON DONOR AND ACCEPTOR FOR MODELING THE PHOTOSYNTHESIS PROCESS
Borovkov, V. V.,Evstigneeva, R. P.,Gribkov, A. A.
, p. 296 - 302 (1995)
We describe methods for synthesis of a triad molecular system based on mesoporphyrin II with electron-donor and electron-acceptor moieties for modeling the primary stage of charge separation in photosynthesis, differing in the order of addition of the donor and the acceptor.Using fluorescent spectroscopy, we have demonstrated quenching-containing coppounds.Investigation of the triad and its zinc complex by kinetic fluorescent spectroscopy allowed us to determine the electron transfer rate constants for the triad and for its zinc complex.
Oxidative heck reaction as a tool for para-selective olefination of aniline: A DFT supported mechanism
Moghaddam, Firouz Matloubi,Pourkaveh, Raheleh,Karimi, Ashkan
, p. 10635 - 10640 (2018/05/31)
This study describes the first para-selective palladium-catalyzed alkenylation of tertiary amines. This regioselective C-H activation was conducted without any chelation moieties. A series of olefins were reacted under mild reaction conditions at 60 °C, and the corresponding products were obtained in good yields with high selectivity.
Microwave-Assisted Synthesis of Phenylpropanoids and Coumarins: Total Synthesis of Osthol
Konrádová, Daniela,Kozubíková, Hana,Dole?al, Karel,Pospí?il, Ji?í
supporting information, p. 5204 - 5213 (2017/09/29)
Herein we describe a one-pot microwave-assisted method for the synthesis of cinnamic acid and coumarin derivatives. The synthesis begins with an aldehyde synthon, and the chosen reaction conditions determine whether a cinnamic acid or coumarin derivative is formed. A regioselective Claisen rearrangement was also efficiently incorporated into the synthetic sequence to further increase the complexity of the product. Notably, this approach provides high product yields and selectivities without the need of a phenol protecting group.
Synthesis of olefins via a Wittig reaction mediated by triphenylarsine
Li, Lun,Stimac, Jared C.,Geary, Laina M.
supporting information, p. 1379 - 1381 (2017/03/17)
An arsine-mediated Wittig reaction for the synthesis of olefins is described. After heating triphenylarsine in the presence of an activated alkyl bromide for 30?min, the resulting arsonium salt condensed with aldehydes in as little as 5?min at room temperature, yielding the olefins in high yields. Aromatic, heteroaromatic, and alkyl aldehydes were all suitable substrates for this process.
METHODS OF TREATMENT USING ARYLCYCLOPROPYLAMINE COMPOUNDS
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Paragraph 0303-0304; 0306, (2014/12/09)
Described herein are methods of treating breast cancer using arylcyclopropylamine compounds.
METHODS OF TREATMENT USING ARYLCYCLOPROPYLAMINE COMPOUNDS
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Paragraph 0221; 0222; 0224, (2013/07/19)
Described herein are methods of treating Parkinson's disease using arylcyclopropylamine compounds.
Synthetic and structural study of 4-phosphacyclohexanones and 3-aza-7-phosphabicyclo[3.3.1]nonan-9-ones
Zayya, Almas I.,Spencer, John L.
experimental part, p. 5109 - 5116 (2012/07/30)
The synthesis of bicyclic phosphorus-nitrogen (PN) compounds containing the rigid bicyclo[3.3.1]nonan-9-one framework was attempted using the Mannich condensation reaction of four different phosphorinanone classes with amines and aldehydes. Three different isomers of 4-tert-butyl-2,6-di(methoxycarbonyl)-3,5- bis(p-dimethylaminophenyl)-4-phosphacyclohexanone were obtained from the Michael addition reaction of tert-butylphosphine with 2,4-di(methoxycarbonyl)-1,5- bis(p-dimethylaminophenyl)penta-1,4-dien-3-one. The reaction of the all-equatorial isomer with methylamine and formaldehyde produced the bicyclic PN compound 7-tert-butyl-1,5-di(methoxycarbonyl)-6,8-bis(p-dimethylaminophenyl)-3- methyl-3-aza-7-phosphabicyclo[3.3.1]nonan-9-one. The identical Mannich reaction of the enol tautomer also yielded the same product, as well as the PN compound 4-tert-butyl-6-methoxycarbonyl-5-(p-dimethylaminophenyl)-2-methyl-2-aza-4- phosphacyclohexanone and the E/Z isomers of 3-(p-dimethylaminophenyl)methyl-2- propenoate. The newly synthesised 3-aza-7-phosphabicyclo[3.3.1]nonan-9-one PN compound adopts a chair-chair conformation both in solution and the solid state.
New synthetic strategies towards psammaplin A, access to natural product analogues for biological evaluation
Baud, Matthias G. J.,Leiser, Thomas,Meyer-Almes, Franz-Josef,Fuchter, Matthew J.
supporting information; experimental part, p. 659 - 662 (2011/03/22)
New synthetic routes towards the natural product psammaplin A were developed with the particular view to preparing diverse analogues for biological assessment. These routes utilize cheap and commercially available starting materials, and allowed access to
Development of tryptase inhibitors derived from thalidomide
Tetsuhashi, Masashi,Ishikawa, Minoru,Hashimoto, Mariko,Hashimoto, Yuichi,Aoyama, Hiroshi
experimental part, p. 5323 - 5338 (2010/09/15)
A novel series of tryptase inhibitors with a N-phenylphthalimide skeleton structurally derived from thalidomide (1) has been developed. Structure-activity relationship studies led to a potent and selective tryptase inhibitor, 2-(4-cyanophenyl)isoindole-1,3-dione-5-yl 3-(2-aminopyridin-5-yl)propanoate (7), with the IC50 value of 78 nM.
Structure-activity relationships of phenylpropanoids as antifeedants for the pine weevil Hylobius abietis
Bohman,Nordlander,Nordenhem,Sunnerheim,Borg-Karlson,Unelius
, p. 339 - 352 (2008/09/18)
Ethyl cinnamate has been isolated from the bark of Pinus contorta in the search for antifeedants for the pine weevil, Hylobius abietis. Based on this lead compound, a number of structurally related compounds were synthesized and tested. The usability of the Topliss scheme, a flow diagram previously used in numerous structure-activity relationship (SAR) studies, was evaluated in an attempt to find the most potent antifeedants. The scheme was initially followed stepwise; subsequently, all compounds found in the scheme were compared. In total, 51 phenylpropanoids were tested and analyzed for SARs by using arguments from the field of medicinal chemistry (rational drug design). Individual Hansch parameters based on hydrophobicity, steric, and electronic properties were examined. The effects of position and numbers of substituents on the aromatic ring, the effects of conjugation in the molecules, and the effects of the properties of the parent alcohol part of the esters were also evaluated. It proved difficult to find strong SARs derived from single physicochemical descriptors, but our study led to numerous new, potent, phenylpropanoid antifeedants for the pine weevil. Among the most potent were methyl 3-phenylpropanoates monosubstituted with chloro, fluoro, or methyl groups and the 3,4-dichlorinated methyl 3-phenylpropanoate.
