208581-37-7Relevant academic research and scientific papers
Efficient light-dependent DNA repair requires a large cofactor separation
Epple, Robert,Carell, Thomas
, p. 7318 - 7329 (2007/10/03)
DNA photolyases are repair enzymes which split (repair) UV-induced cyclobutane DNA lesions. Critical steps in the light-driven repair reaction are the absorption of light by a deazaflavin or methenyl tetrahydrofolate cofactor and the transfer of the excit
Flavin- and deazaflavin-containing model compounds mimic the energy transfer step in type-II DNA-photolyases
Epple, Robert,Carell, Thomas
, p. 938 - 941 (2007/10/03)
A distinct energy transfer between the deazaflavin and the flavin is observed in compounds that mimic the DNA repair function of DNAphotolase enzymes (see sketch). Studies on these models prove that the deazaflavin acts solely as photoantenna and suggest
