208659-01-2

Upstream product

• 208658-91-7 (E)-7-Benzyloxy-5-methylene-hept-2-en-1-ol 
• 208658-85-9 (2R,3R)-5-[2-(benzyloxy)ethyl]-2,3-epoxy-5-en-1-hexanol 
• 208658-97-3 Benzoic acid (R)-7-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-methylene-heptyl ester 
• 208714-06-1 (R)-4-(4-Benzyloxy-2-methylene-butyl)-2-(4-methoxy-phenyl)-[1,3]dioxane 
• 208658-95-1 Benzoic acid (R)-7-benzyloxy-3-hydroxy-5-methylene-heptyl ester 
• 208658-99-5 (R)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-methylene-heptan-1-ol 
• 208658-83-7 (R)-7-Benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-5-methylene-heptanal 
• 208658-93-9 (R)-7-Benzyloxy-5-methylene-heptane-1,3-diol 
• 58558-53-5 (((3-methylbut-3-en-1-yl)oxy)methyl)benzene 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 208659-00-1 (1R,5R)-3-[2-Benzyloxy-eth-(Z)-ylidene]-5-(tert-butyl-dimethyl-silanyloxy)-cyclohexanol 
• 208714-02-7 (1R,3R)-5-(2-Benzyloxy-ethylidene)-cyclohexane-1,3-diol 

Downstream Products

• 139356-39-1 (1R,3R)-1,3-bis((tert-butyldimethyl)silanyloxy)-5-[2-(diphenylphosphinoyl)-ethylidene]cyclohexane 
• 139356-38-0 ((1R,3R)-5-(2-chloroethylidene)cyclohexane-1,3-diyl)bis(oxy)bis(tert-butyldimethylsilane) 
• 139356-37-9 [(3R,5R)-3,5-bis-(tert-butyldimethylsilanyloxy)cyclohexylidene]-ethanol 

Relevant academic research and scientific papers

Asymmetric synthesis of a key ring a synthon for 1α-hydroxy-19-nor vitamin D

A diasteroselective carbonyl ene reaction on a substrate obtained from a regioselective propiolate ene reaction is described for the synthesis of 19- nor A-ring synthon 3.

"Symmetry" in the synthesis of the A-ring of a vitamin D hybrid analogue with significant transactivation activity: A combinatorial sequence of regioselective propiolate-ene, catalytic enantioselective epoxidation and carbonyl-ene cyclization reactions

The combination of the regioselective propiolate-ene reaction, catalytic enantioselective epoxidation and catalytic enantioselective carbonyl-ene cyclization completes the synthesis of the A ring of the hybrid 19-nor-22-oxa D3 analogue (1), which shows the significant activity in transactivation.