208755-97-9

Upstream product

• 208755-94-6 [(2R)-2-azido-4-benzyloxy-3,3-difluorobutan-1-yl](tert-butyldiphenylsilyl)ether 
• 208755-93-5 (S)-4-Benzyloxy-1-(tert-butyl-diphenyl-silanyloxy)-3,3-difluoro-butan-2-ol 
• 208755-95-7 (R)-2-Azido-4-benzyloxy-3,3-difluoro-butan-1-ol 
• 208755-90-2 2-Benzyloxy-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethanone 
• 208755-91-3 (S)-4-(2-Benzyloxy-1,1-difluoro-ethyl)-2,2-dimethyl-[1,3]dioxolane 
• 208755-92-4 (2S)-4-(benzyloxy)-3,3-difluorobutane-1,2-diol 
• 117399-58-3 (1S)-2-(benzyloxy)-1-[(4S)-2,2-dimethyl-1,3-dioxolane-4-yl]-ethan-1-ol 
• 100-39-0 benzyl bromide 
• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 
• 208755-96-8 (R)-2-Azido-4-benzyloxy-3,3-difluoro-butyric acid 

Relevant academic research and scientific papers

Synthesis of β-difluorine-containing amino acids

A convenient strategy was developed to prepare several β-difluoroamino acids. As exemplified by the synthesis of 3,3-difluoro-L-homocysteine, 3,3- difluoro-L-homoserine and 3,3-difluoro-L-methionine, the reaction sequence all started from L-isoascorbic acid. This approach holds potential to be extended to make other β-difluorine-containing amino acids.