20892-46-0

Usage

Uses

Used in Organic Synthesis:
N,N-dimethyl-1H-indole-1-propylamine is utilized as a reagent in organic synthesis for the preparation of various indole derivatives. Its unique structure allows for the creation of a wide range of chemical compounds, making it a valuable component in the synthesis process.
Used in Pharmaceutical Production:
As a precursor, N,N-dimethyl-1H-indole-1-propylamine is used in the production of pharmaceuticals. Its potential role in creating new drugs is significant, given the versatility of the indole ring in medicinal chemistry.
Used in Agrochemical Production:
Similarly, N,N-dimethyl-1H-indole-1-propylamine serves as a precursor in the development of agrochemicals, contributing to the creation of products designed to enhance crop protection and yield.
Used in Pharmacological Research:
N,N-dimethyl-1H-indole-1-propylamine has been studied for its potential psychoactive properties, which may have implications in the field of pharmacology. Its effects on the central nervous system are of particular interest, although more research is needed to fully understand its mechanisms of action and potential therapeutic applications.
However, due to the potential hazards associated with N,N-dimethyl-1H-indole-1-propylamine and the lack of comprehensive toxicological studies, it is crucial that N,N-dimethyl-1H-indole-1-propylamine be handled and used with caution to ensure safety in research and industrial applications.

InChI:InChI=1/C13H18N2/c1-14(2)9-5-10-15-11-8-12-6-3-4-7-13(12)15/h3-4,6-8,11H,5,9-10H2,1-2H3

Upstream product

• 4414-79-3 3-(1H-indol-1-yl)propanenitrile 
• 124-40-3 dimethyl amine 
• 120-72-9 indole 
• 109-54-6 3-(Dimethylamino)propyl chloride 
• 5407-04-5 3-(dimethylamino)propyl chloride hydrochloride 

Relevant academic research and scientific papers

N-SUBSTITUTED INDOLES AND OTHER HETEROCYCLES FOR TREATING BRAIN DISORDERS

The present invention provides N-substituted indoles and other heterocycles and methods of using the compounds for treating brain disorders.

Identification of Psychoplastogenic N, N-Dimethylaminoisotryptamine (isoDMT) Analogues through Structure-Activity Relationship Studies

Ketamine, N,N-dimethyltryptamine (DMT), and other psychoplastogens possess enormous potential as neurotherapeutics due to their ability to potently promote neuronal growth. Here, we report the first-ever structure-Activity relationship study with the explicit goal of identifying novel psychoplastogens. We have discovered several key features of the psychoplastogenic pharmacophore and used this information to develop N,N-dimethylaminoisotryptamine (isoDMT) psychoplastogens that are easier to synthesize, have improved physicochemical properties, and possess reduced hallucinogenic potential as compared to their DMT counterparts.

NB 06: From a simple lysosomotropic aSMase inhibitor to tools for elucidating the role of lysosomes in signaling apoptosis and LPS-induced inflammation

Ceramide generation is involved in signal transduction of cellular stress response, in particular during stress-induced apoptosis in response to stimuli such as minimally modified Low-density lipoproteins, TNFalpha and exogenous C6-ceramide. In this paper we describe 48 diverse synthetic products and evaluate their lysosomotropic and acid sphingomyelinase inhibiting activities in macrophages. A stimuli-induced increase of C16-ceramide in macrophages can be almost completely suppressed by representative compound NB 06 providing an effective protection of macrophages against apoptosis. Compounds like NB 06 thus offer highly interesting fields of application besides prevention of apoptosis of macrophages in atherosclerotic plaques in vessel walls. Most importantly, they can be used for blocking pH-dependent lysosomal processes and enzymes in general as well as for analyzing lysosomal dependent cellular signaling. Modulation of gene expression of several prominent inflammatory messengers IL1B, IL6, IL23A, CCL4 and CCL20 further indicate potentially beneficial effects in the field of (systemic) infections involving bacterial endotoxins like LPS or infections with influenza A virus.

Inhibition of dynamin mediated endocytosis by the Dynoles - Synthesis and functional activity of a family of indoles

Screening identified two bisindolylmaleimides as 100 μM inhibitors of the GTPase activity of dynamin I. Focused library approaches allowed development of indole-based dynamin inhibitors called dynoles. 100-Fold in vitro enhancement of potency was noted with the best inhibitor, 2-cyano-3-(1-(2- (dimethylamino)ethyl)-1H-indol-3-yl)-N-octylacrylamide (dynole 34-2), a 1.3 ± 0.3 μM dynamin I inhibitor. Dynole 34-2 potently inhibited receptor mediated endocytosis (RME) internalization of Texas red-transferrin. The rank order of potency for a variety of dynole analogues on RME in U2OS cells matched their rank order for dynamin inhibition, suggesting that the mechanism of inhibition is via dynamin. Dynoles are the most active dynamin I inhibitors reported for in vitro or RME evaluations. Dynole 34-2 is 15-fold more active than dynasore against dynamin I and 6-fold more active against dynamin mediated RME (IC50 ～15 μM; RME IC50 ～80 μM). The dynoles represent a new series of tools to better probe endocytosis and dynamin-mediated trafficking events in a variety of cells.