208927-49-5Relevant academic research and scientific papers
Synthesis of γ-fluoro-α-methyl-α-amino acids. A new alkylation procedure for ester imines
Haufe, Guenter,Laue, Klaus Wilhelm,Triller, Michael Ulrich,Takeuchi, Yoshio,Shibata, Norio
, p. 5929 - 5938 (1998)
Deprotonation of alanine ester imines with KO'Bu in DMSO or DMF and alkylation of the formed enolates with several 2-fluoroalkyl halogenides 2 and subsequent hydrolysis of the imino and the ester groups are presented as an efficient three-step sequence for the synthesis of racemic title compounds 5.
