1786-36-3

Usage

Uses

Used in Chemical Synthesis Industry:
1-(2-Bromo-1-fluoroethyl)benzene is used as a reactant for the bromofluorination of alkenes. This process involves the use of N-bromosuccinimide (NBS) combined with triethylamine tris(hydrofluoride) to selectively introduce bromine and fluorine atoms onto the alkene substrate. The bromofluorination reaction is valuable for the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals, where the presence of both halogens can significantly influence the reactivity and properties of the final product.

Upstream product

• 100-42-5 styrene 
• 2932-58-3 2-fluoro-2-phenylethanol 
• 28078-73-1 methyl hypobromite 
• 10218-90-3 dimethyl-N-bromoamine 
• 100-52-7 benzaldehyde 

Downstream Products

• 696-31-1 α-fluorostyrene 
• 1786-56-7 Salpetersaeure-<2-fluor-2-phenyl-ethylester> 
• 115046-20-3 phenyl-2 fluoro-2 azido-1 ethane 
• 208927-49-5 2-(Benzhydrylidene-amino)-4-fluoro-4-phenyl-butyric acid ethyl ester 
• 33315-78-5 2-acetoxy-1-fluoro-1-phenylethane 

Relevant academic research and scientific papers

Synthesis of sp 3-Enriched β-Fluoro Sulfonyl Chlorides

A three-step approach to the synthesis of sp 3-enriched β-fluoro sulfonyl chlorides starting from alkenes is reported. The method was successfully applied to a wide range of acyclic and cyclic substrates, bearing either an exocyclic or an endocyclic double bond. The procedure worked with a wide range of substrates and tolerated a number of functional and protecting groups. Moreover, the target cyclic compounds were obtained as single cis diastereomers on a multigram scale. The title compounds are promising building blocks for drug discovery that can be used to obtain sp 3-enriched β-fluoro and α,β-unsaturated sulfonamides.

Chiral phosphoric acid catalyzed enantioselective [4 + 2] cycloaddition reaction of α-fluorostyrenes with imines

An enantioselective [4 + 2] cycloaddition reaction of α-fluorostyrenes with N-benzoyl imines was demonstrated using a chiral phosphoric acid catalyst. Cycloaddition products having fluorine functionality were formed in high yields with excellent diastereo

Design of fluorinated cyclopropane derivatives of 2-phenylcyclopropylmethylamine leading to identification of a selective serotonin 2C (5-HT2C) receptor agonist without 5-HT2B agonism

A new series of fluorinated 5-HT2C agonists were designed and synthesized on the basis of our previous work on 2-phenylcyclopropylmethylamines as a potential approach for the treatment of central nervous system disorders. Key fluorinated cyclop

Fluorinated cyclopropanes: Synthesis and chemistry of the aryl α,β,β-trifluorocyclopropane motif

A general route to aryl α,β,β-trifluorocyclopropanes is reported and aryl oxidation gave the corresponding α,β,β-trifluorocyclopropane carboxylic acid. Reactions of the corresponding amides with phenol/thiophenol resulted in HF elimination and then conjugate addition. The partially fluorinated cyclopropane has a similar lipophilicity to -CF3 despite three carbon atoms, and it emerges as a novel motif for drug discovery.

Bromofluorination of unsaturated compounds using DMPU/HF as a fluorinating reagent

Bromofluorination reactions were performed by treating of a variety of unsaturated compounds with N-bromosuccinimide (NBS) and DMPU/HF as the fluorinating reagent. The DMPU/HF complex showed to be an efficient fluorinating reagent to convert alkenes into

(HETERO)ARYL CYCLOPROPYLAMINE COMPOUNDS AS LSD1 INHIBITORS

The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula (I) as described and defined herein, and their use in therapy, including, e.g., in the treatment or prevention of cancer, a neurological disease or condition, or a viral infection.

Halofluorination of alkenes mediated by 1,1,3,3,3-pentafluoropropene- diethylamine adduct

1,1,3,3,3-Pentafluoropropene-diethylamine complex (PFPDEA) has been found useful as a fluoride source in halofluorination reactions of various olefins. Reactions proceeded with PFPDEA and N-halosuccinimide (NXS, X = Br, I) or 1,3-dibromo-5,5-dimethylhydan

Halofluorination of alkenes mediated by 1,1,3,3,3-pentafluoropropene- diethylamine adduct

1,1,3,3,3-Pentafluoropropene-diethylamine complex (PFPDEA) has been found useful as a fluoride source in halofluorination reactions of various olefins. Reactions proceeded with PFPDEA and N-halosuccinimide (NXS, X = Br, I) or 1,3-dibromo-5,5-dimethylhydan

Halofluorination of alkenes using trihaloisocyanuric acids and HF-pyridine

Halofluorination of alkenes with a new system (trihaloisocyanuric acids and HF-pyridine) results in the formation of vicinal halofluoroalkanes. The reaction is regioselective leading to Markovnikov-oriented products and the halofluorinated adducts follow anti-addition in the case of cyclohexene and 1-methylcyclohexene. Reaction yields range from 67-88%. Georg Thieme Verlag Stuttgart · New York.

Asymmetric epoxidation of fluoroolefins by chiral dioxirane. Fluorine effect on enantioselectivity

(Chemical Equation Presented) The asymmetric epoxidation of various fluoroolefins has been studied using chiral ketone catalyst, and up to 93% ee was achieved with fructose-derived ketone 1.