20895-91-4Relevant academic research and scientific papers
Synthesis method of 5-chloroquinoline-4-ol
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Paragraph 0036-0038; 0042-0044; 0048-0050, (2021/01/20)
The invention provides a synthesis method of 5-chloroquinoline-4-ol, and relates to the technical field of pharmaceutical synthesis. The method comprises the following steps of: reacting 2-amino-6-chlorobenzonitrile serving as a raw material with methyl m
Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: Structure-activity relationship elucidation
Peters, Jens-Uwe,Luebbers, Thomas,Alanine, Alexander,Kolczewski, Sabine,Blasco, Francesca,Steward, Lucinda
, p. 256 - 261 (2008/12/23)
The optimisation of affinity and selectivity in a novel series of dual 5-HT5A/5-HT7 receptor ligands is described. Brain penetrant 2-aminodihydroquinazolines with low nanomolar affinities were identified.
5-Chloro-4-alkyl-3,4-dihydro-quinazolin-2-ylamine derivatives
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Page/Page column 6, (2010/11/25)
The present invention relates to compounds of formula I wherein R1, R2, R3 are as described in the specification and pharmaceutically acceptable acid addition salts and tautomers thereof. Compounds of formula I have good a
Process for the preparation of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones
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, (2008/06/13)
A new process has been developed for the synthesis of optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]quinazolin-2-ones. In particular, the process is particularly adaptable for the preparation of the 5,6-disubstituted compounds, e.g., 5,6-dimethyl-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolin-2-one. The compounds so prepared are useful as blood platelet anti-aggregative and/or antihypertensive agents in mammals, including humans.
