Bioorganic and Medicinal Chemistry Letters p. 1139 - 1144 (1998)
Update date:2022-08-05
Topics:
Tandon, Manish
Wu, Min
Begley, Tadhg P.
Myllyharju, Johanna
Pirskanen, Asta
Kivirikko, Kari
Proline analogs (3-F, 3-Cl, 3-Br, 3,3-cyclopropyl, 3,3-methylene, 3-Me, and 4-Me) were synthesized, incorporated into CbzGlyPheXGlyOEt, and tested as substrate analogues/mechanistic probes for the human prolyl-4-hydroxylase catalyzed hydroxylation reaction. With the exception of the 3-fluoroproline containing peptide, none of these peptides were substrates for the enzyme.
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(1968)
