Bioorganic and Medicinal Chemistry Letters p. 1139 - 1144 (1998)
Update date:2022-08-05
Topics:
Tandon, Manish
Wu, Min
Begley, Tadhg P.
Myllyharju, Johanna
Pirskanen, Asta
Kivirikko, Kari
Proline analogs (3-F, 3-Cl, 3-Br, 3,3-cyclopropyl, 3,3-methylene, 3-Me, and 4-Me) were synthesized, incorporated into CbzGlyPheXGlyOEt, and tested as substrate analogues/mechanistic probes for the human prolyl-4-hydroxylase catalyzed hydroxylation reaction. With the exception of the 3-fluoroproline containing peptide, none of these peptides were substrates for the enzyme.
View MoreHenan Techway Chemical Co.,Ltd.
website:http://www.techwaychem.com
Contact:+86-371-66380080
Address:No.27 Shunhe Road,
Tianjin SPHINX SCIENTIFIC LAB.
Contact:+86-022-66211289
Address:Tianda high-tech Park. No.80,the 4th Avenue
Shijiazhuang Sdyano Fine Chemical Co., Ltd
Contact:+86-311-89830448
Address:NO.48 Ta Nan Road,Yuhua District,Shijiazhuang,Hebei,China
Suzhou Kangrun Pharmaceutical, Inc
Contact:86-512-63912376，63913329
Address:Building 2, No. 2358 ,Chang'an Rd, Wujiang Economic Development Zone Pioneering park, china
Contact:+86-571-87010026
Address:202, Zhenhua Road,
Doi:10.1039/a800779i
(1998)Doi:10.1080/00397919708005025
(1997)Doi:10.1016/S0040-4020(00)00316-1
(2000)Doi:10.1021/acs.orglett.6b03087
(2016)Doi:10.1021/om9800849
(1998)Doi:10.1039/c19680001149
(1968)
