20928-01-2

Basic information

• Product Name: dibenzo[b,d]furan-2-yl acetate
• CAS NO: 20928-01-2
• Molecular Formula: C₁₄H₁₀O₃
• Molecular Weight: 226.2274
• Mol File: 20928-01-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 367.5°C at 760 mmHg
• Flash Point: 176.1°C
• Density: 1.27g/cm³
• Vapor Pressure: 1.36E-05mmHg at 25°C
• Refractive Index: 1.657
• CAS DataBase Reference: dibenzo[b,d]furan-2-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: dibenzo[b,d]furan-2-yl acetate(20928-01-2)
• EPA Substance Registry System: dibenzo[b,d]furan-2-yl acetate(20928-01-2)

Safety Data

• Hazardous Substances Data: 20928-01-2(Hazardous Substances Data)

Upstream product

• 86-77-1 2-hydroxydibenzofuran 
• 108-24-7 acetic anhydride 
• 132-64-9 dibenzofuran 
• 75-36-5 acetyl chloride 
• 13761-32-5 2-acetyldibenzofuran 

Downstream Products

• 1228443-53-5 N-[(4-chlorophenyl)(2-hydroxydibenzofuran-1-yl)methyl]benzamide 
• 1228443-54-6 N-[(2-hydroxydibenzofuran-1-yl)(3,4,5-trimethoxyphenyl)methyl]acetamide 
• 1228443-55-7 N-[(2-hydroxydibenzofuran-1-yl)(3,4,5-trimethoxyphenyl)methyl]benzamide 
• 1228443-56-8 N-[(2-hydroxydibenzofuran-1-yl)(3,4,5-trimethoxyphenyl)methyl]urea 
• 1228443-57-9 N-[(4-bromophenyl)(2-hydroxydibenzofuran-1-yl)methyl]urea 
• 1228443-59-1 N-[(2-hydroxydibenzofuran-1-yl)(4-methoxyphenyl)methyl]acetamide 
• 1228443-60-4 N-[(2-hydroxydibenzofuran-1-yl)(4-methoxyphenyl)methyl]urea 
• 1228443-64-8 1-(4-chlorophenyl)-1H-benzo[2,3]benzofuro[4,5-e][1,3]oxazin-3(2H)-one 
• 1228443-65-9 1-(4-bromophenyl)-1H-benzo[2,3]benzofuro[4,5-e][1,3]oxazin-3(2H)-one 
• 1228443-67-1 1-(4-methoxyphenyl)-1H-benzo[2,3]benzofuro[4,5-e][1,3]oxazin-3(2H)-one 
• 1228443-68-2 1-(3,4,5-trimethoxyphenyl)-1H-benzo[2,3]benzofuro[4,5-e][1,3]oxazin-3(2H)-one 
• 1228443-50-2 N-[(2-hydroxydibenzofuran-1-yl)(phenyl)methyl]acetamide 
• 1228443-51-3 N-[(4-chlorophenyl)(2-hydroxydibenzofuran-1-yl)methyl]acetamide 
• 1228443-52-4 N-[(4-chlorophenyl)(2-hydroxydibenzofuran-1-yl)methyl]urea 

Relevant articles and documents

-

-

Preparation method of ganoderma lucidum furan A

The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of ganoderma lucidum furan A. According to the preparation method of the ganodermalucidum furan A, a compound shown in a general formula II and a compound shown in a general formula III are subjected to condensation reaction to obtain a compound shown in a general formula I, and the reaction equation is as shown in the specification. According to the technical scheme provided by the invention, a synthetic route which is particularly suitable for amplifying and synthesizing theganoderma lucidum furan A is provided; the selected raw materials, namely dibenzofuran and 2-methyl-2-butenal, are mature chemical products; the method has the advantages of simple process, wide source, low price, mild reaction conditions of the whole reaction route and no special requirements, the obtained intermediate can be directly subjected to subsequent reactions without purification, the route completely overcomes the defects of the synthesis route in the prior art due to the elements, and the method has the prospect of industrial large-scale production.

Synthesis and antitubercular evaluation of amidoalkyl dibenzofuranols and 1H-benzo[2,3]benzofuro[4,5-e][1,3]oxazin-3(2H)-ones

A new class of amidoalkyl dibenzofuranols and 1H-benzo[2,3]benzofuro[4,5-e] [1,3]oxazin-3(2H)-ones was synthesized in very good yields through polyphosphoric acid supported on silica (PPA-SiO2) catalyzed one-pot three component condensation of 2-dibenzofuranol; aromatic aldehydes and acetamide or benzamide or urea under solvent free conditions. At 125 °C the reaction led to the formation of amidoalkyl dibenzofuranols 5a-k where as at 160 °C cyclization take place to give oxazin-3(2H)-one analogues 6a-e. Screening all the 16 compounds for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv (MTB) resulted 1-((4-chlorophenyl)(2- hydroxydibenzo[b,d]furanyl)methyl)urea 5h; 1-((4-bromophenyl)(2- hydroxydibenzo[b,d]furanyl)methyl)urea 5i; 1-phenyl-1H-benzo[2,3]benzo furo[4,5-e][1,3]oxazin-3(2H)-one 6a (MIC 3.13 μg/mL) and 1-(4-chlorophenyl)- 1H-benzo[2,3]benzofuro[4,5-e][1,3]oxazin-3(2H)-one 6b; 1-(4-bromophenyl)-1H- benzo[2,3]benzofuro [4,5-e][1,3]oxazin-3(2H)-one 6c (MIC 1.56 μg/mL) as most active antitubercular agents.