2093243-16-2 Usage
Uses
Used in Pharmaceutical Industry:
Methyl-3-(hydroxy(phenyl)methylene)-2-oxoindoline-6-carboxylate is used as a key intermediate for the synthesis of nintedanib esylate, a drug used in the treatment of idiopathic pulmonary fibrosis (IPF). The compound's unique structure allows for the development of nintedanib, which targets specific cellular pathways involved in the progression of IPF, thereby providing a therapeutic option for patients suffering from this debilitating disease.
Check Digit Verification of cas no
The CAS Registry Mumber 2093243-16-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 2,0,9,3,2,4 and 3 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2093243-16:
(9*2)+(8*0)+(7*9)+(6*3)+(5*2)+(4*4)+(3*3)+(2*1)+(1*6)=142
142 % 10 = 2
So 2093243-16-2 is a valid CAS Registry Number.
2093243-16-2Relevant academic research and scientific papers
An improved process for the synthesis of nintedanib esylate
Arava, Veerareddy,Gogireddy, Surendrareddy
, p. 975 - 981 (2017/05/04)
Nintedanib esylate is synthesized via novel intermediates of (Z)-methyl 3-(acetoxy-phenyl)methylene)-1-acetyl-2-oxoindoline-6-carboxylate and N-(4-aminophenyl)-2-chloro-N-methylacetamide in good yields.
POLYMORPH OF NINTEDANIB ETHANESULPHONATE, PROCESSES AND INTERMEDIATES THEREOF
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Page/Page column 25; 26, (2016/11/21)
The present invention provides novel crystalline Form of Nintedanib and process for its preparation. The present invention also provides to a novel process for the preparation of Nintedanib. The present invention further provides to novel intermediates used in the preparation of Nintedanib and process for their preparation.
