209328-87-0

Basic information

• Product Name: 2-FLUORO-3-HYDROXY-6-PICOLINE
• Synonyms: 2-FLUORO-3-HYDROXY-6-PICOLINE;3-Pyridinol,2-fluoro-6-methyl-(9CI);2-FLUORO-3-HYDROXY-6-METHYLPYRIDINE;2-Fluoro-6-Methylpyridin-3-ol
• CAS NO: 209328-87-0
• Molecular Formula: C₆H₆FNO
• Molecular Weight: 127.12
• Product Categories: PYRIDINE;Pyridines;Boronic Acid
• Mol File: 209328-87-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 289.4 °C at 760 mmHg
• Flash Point: 128.8 °C
• Appearance: /
• Density: 1.252 g/cm³
• Vapor Pressure: 0.00127mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.26±0.10(Predicted)
• CAS DataBase Reference: 2-FLUORO-3-HYDROXY-6-PICOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-3-HYDROXY-6-PICOLINE(209328-87-0)
• EPA Substance Registry System: 2-FLUORO-3-HYDROXY-6-PICOLINE(209328-87-0)

Safety Data

• Hazardous Substances Data: 209328-87-0(Hazardous Substances Data)

Usage

General Description

2-Fluoro-3-Hydroxy-6-Picoline is a specialized chemical mainly used in organic synthesis. It is known for its fluorine content and belongs to the group of picoline chemicals. It has a picoline structure with a hydroxy and a fluoro group attached at different positions. The particular physical and chemical properties of this chemical, derived from its specific structure, make it suitable for various niche applications. As with most chemicals of this type, it requires precise handling and storage conditions, with safety precautions necessary to prevent any risk of hazard or injury during its handling or use.

InChI:InChI=1/C6H6FNO/c1-4-2-3-5(9)6(7)8-4/h2-3,9H,1H3

Upstream product

• 20348-16-7 2-amino-3-hydroxy-6-methylpyridine 
• 15128-90-2 6-methyl-2-nitropyridin-3-ol 

Downstream Products

• 1005515-12-7 3-Ethoxy-2-fluoro-6-methylpyridine 

Relevant articles and documents

Targeting cyclic nucleotide phosphodiesterase 5 (PDE5) in brain: Toward the development of a PET radioligand labeled with fluorine-18

With the aim to develop a specific radioligand for imaging the cyclic nucleotide phosphodiesterase 5 (PDE5) in brain by positron emission tomography (PET), seven new fluorinated inhibitors (3–9) were synthesized on the basis of a quinoline core. The inhibitory activity for PDE5 together with a panel of other PDEs was determined in vitro and two derivatives were selected for IC50 value determination. The most promising compound 7 (IC50 = 5.92 nM for PDE5A), containing a 3-fluoroazetidine moiety, was further radiolabeled by aliphatic nucleophilic substitution of two different leaving groups (nosylate and tosylate) using [18F]fluoride. The use of the nosylate precursor and tetra-n-butyl ammonium [18F]fluoride ([18F]TBAF) in 3-methyl-3-pentanol combined with the addition of a small amount of water proved to be the best radiolabeling conditions achieving a RCY of 4.9 ± 1.5% in an automated procedure. Preliminary biological investigations in vitro and in vivo were performed to characterize this new PDE5 radioligand. Metabolism studies of [18F]7 in mice revealed a fast metabolic degradation with the formation of radiometabolites which have been detected in the brain.