20937-29-5

Upstream product

• 20937-65-9 6-Isobutyryl-1-methyl-cyclohexen 
• 108-94-1 cyclohexanone 
• 38127-47-8 2-bromocyclohex-1-ene-1-carbaldehyde 
• 1279102-52-1 1-(2-bromocyclohex-1-en-1-yl)-2-methylpropan-1-one 
• 75-16-1 methylmagnesium bromide 
• 1279102-51-0 1-(2-bromocyclohex-1-en-1-yl)-2-methylpropan-1-ol 
• 591-49-1 1-methylcyclohex-1-ene 
• 79-30-1 isobutyryl chloride 

Downstream Products

• 1279102-63-4 C₁₄H₂₆OSi 

Relevant academic research and scientific papers

Enabling the development of N-Heterocyclic Carbene (NHC) catalyzed reactions: Practical methods for the preparation of 1-acyl-2-alkylcycloalkenes from cycloalkanones

The synthesis of 1-acyl-2-alkylcycloalkenes from a variety of cycloalkanones has been achieved via either-keto enol phosphates or-bromoenones. Both methods exploit simple and readily scalable transformations allowing the preparation of the desired compoun

N-heterocyclic carbene-catalyzed (4 + 2) cycloaddition/decarboxylation of silyl dienol ethers with α,β-unsaturated acid fluorides

Herein we report the first all-carbon N-heterocyclic carbene-catalyzed (4 + 2) cycloaddition. The reaction proceeds with α,β-unsaturated acid fluorides and silyl dienol ethers and produces 1,3-cyclohexadienes with complete diastereocontrol (dr >20:1) while demonstrating a new type of reaction cascade exploiting α,β-unsaturated acyl azoliums.

Novel Acylation of Aliphatic Olefins Promoted by Active Zinc Compounds

It was found that acylation of a variety of aliphatic olefins with acid chlorides is efficiently promoted by active zinc compounds, which were prepared from a Zn/Cu couple and alkyl iodides.The crude product mixtures were subsequently treated with 1 M KOH in methanol or were subjected to catalytic hydrogenation to afford the corresponding α,β-unsaturated or saturated ketones in good to moderate yields.It was also shown that the reaction fully follows the Markovnikov rule.