20946-01-4Relevant academic research and scientific papers
An efficient and modified biginelli-type synthesis of 3,4-dihydro-1H-indeno[1,2-d]pyrimidine-2,5-dione using phosphorous pentoxide
Warekar, Poojali P.,Kolekar, Govind B.,Deshmukh, Madhukar B.,Anbhule, Prashant V.
supporting information, p. 3594 - 3601 (2015/08/11)
A simple, clean and convenient one-pot method has been developed for the synthesis of 4-phenyl-3,4-dihydro-1H-indeno[1,2-d]pyrimidine-2,5-dione and 4-phenyl-2-thioxo-1,2,3,4-tetrahydro-5H-indeno[1,2-d]pyrimidine-5-one by multicomponent condensation of 1,3-indanedione, aromatic aldehydes and urea/thiourea using phosphorus pentoxide in ethanol under reflux conditions. The simple workup procedure and moderate to good yields within short time are some important features of this protocol. The synthesized compounds have been interpreted on the basis of their spectroscopic data.
Design, synthesis, characterization, and antimicrobial activity of biginelli products of indandione
Dabholkar, Vijay V.,Patil, Sunil R.,Pandey, Rajesh V.
, p. 929 - 932 (2012/10/29)
A simple and efficient method has been developed for the synthesis of 4-(substituted phenyl)-3,4-dihydro-1H-indeno [1,2-d] pyrimidine-2,5-dione (5) and 4-(substituted phenyl)-2-thioxo-1,2,3,4-tetrahydroindeno [1,2-d] pyrimidine-5-one (6), by a one-pot three component cyclocondensation reaction of 1,3 dicarbonyl compound (Indandione) (1), aromatic aldehyde (2), and urea/thiourea (3/4) using catalytic amount of conc. HCl in refluxing ethanol. Representative samples were screened for their antimicrobial activity against gram-negative bacteria, E coli and Paeruginosa and gram-positive bacteria, S aureus, and C diphtheriae using disc diffusion method. The structures of the products were confirmed by IR, 1H, 13C NMR, and elemental analysis.
Tricyclic 3,4-dihydropyrimidine-2-thione derivatives as potent TRPA1 antagonists
Gijsen, Harrie J.M.,Berthelot, Didier,De Cleyn, Michel A.J.,Geuens, Ivo,Brone, Bert,Mercken, Marc
scheme or table, p. 797 - 800 (2012/03/11)
The transient receptor potential A1 (TRPA1) channel has been implicated in a number of inflammatory and nociceptive processes, and antagonists of the TRPA1 receptor could offer a potential treatment for conditions such as inflammatory or neuropathic pain,
Synthesis of fused dihydropynmidinones from cyclic-1,3-dicarbonyl compounds: Modified Biginelli synthesis of 1,2,3,4,5,6,7,8- octahydroquinazolinediones and 3,4-dihydro-1H-indeno[1,2-d]pyrimidine-2,5-diones
Shanmugam, Pachaiyappan,Sabastein, Cruz,Perumal, Paramasivan T.
, p. 135 - 140 (2007/10/03)
Syntheses of bicyclo-3,4-dihydropyrimidinediones from cyclic 1,3-diketones such as 5,5-dimethyl-1,3-cyclohexanedione (dimedone) and 1,3-indanedione have been attempted. During the multicomponent coupling of dimedone with (thio)urea and aldehydes, the unpr
SYNTHESIS AND REACTIONS OF 2,3-DIHYDRO-5-ARYL-5H,6H-THIAZOLO-2,4-DIAZAFLUORENE-3,6-DIONES OF POTENTIAL BIOLOGICAL ACTIVITIES
Ali, Mohamed I.,El-Fotooh, Abou,Hamman, G.,Mohamed, Salwa F.
, p. 211 - 216 (2007/10/02)
1,2,3,4-Tetrahydro-1-aryl-3,9-dioxo-2,4-diazafluorenes (2) and 1,2,3,4-tetrahydro-1-aryl-9-oxo-3-thioxo-2,4-diazafluorenes (3) were newly synthesized.Compounds 3 reacted with chloroacetic acid, α-bromopropanoic acid, or Β-bromopropanoic acid in the presen
