209460-09-3

Basic information

• Product Name: 1-[5-chloro-2-(tritylamino)phenyl]-2,2,2-trifluoroethan-1-one
• Synonyms: 1-[5-chloro-2-(tritylamino)phenyl]-2,2,2-trifluoroethan-1-one
• CAS NO: 209460-09-3
• Molecular Weight: 465.902
• Mol File: 209460-09-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-[5-chloro-2-(tritylamino)phenyl]-2,2,2-trifluoroethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[5-chloro-2-(tritylamino)phenyl]-2,2,2-trifluoroethan-1-one(209460-09-3)
• EPA Substance Registry System: 1-[5-chloro-2-(tritylamino)phenyl]-2,2,2-trifluoroethan-1-one(209460-09-3)

Safety Data

• Hazardous Substances Data: 209460-09-3(Hazardous Substances Data)

Upstream product

• 861359-74-2 diisopropylethyl amine 
• 76-84-6 triphenylmethyl alcohol 
• 1184936-21-7 4-Chloro-2-trifluoroacetyl-aniline, hydrochloride hydrate 
• 76-83-5 trityl chloride 
• 154598-53-5 1-(2-amino-5-chloro-phenyl)-2,2,2-trifluoro-ethanone 
• 106-47-8 4-chloro-aniline 
• 65854-91-3 N-(4-chlorophenyl)-2,2-dimethylpropionamide 
• 214353-17-0 4-chloro-2-trifluoroacetylaniline hydrochloride hydrate 

Downstream Products

• 1042738-43-1 4-(5-chloro-2-(tritylamino)phenyl)-5,5,5-trifluoro-4-hydroxypentan-2-one 
• 168834-41-1 2-(2'-amino-5'-chlorophenyl)-1,1,1-trifluoro-4-phenylbut-3-yn-2-ol 
• 221177-51-1 trans-6-Amino-3-chloro-α-(2-cyclopropylethenyl)-α-(trifluoromethyl)benzyl alcohol 

Relevant articles and documents

Asymmetric synthesis of benzoxazinones

The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (VI-i) STR1 which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

Practical asymmetric synthesis of Efavirenz (DMP 266), an HIV-1 reverse transcriptase inhibitor

A highly enantioselective and practical synthesis of the HIV-1 reverse transcriptase inhibitor efavirenz (1) is described. The synthesis proceeds in 62% overall yield in seven steps from 4-chloroaniline (6) to give efavirenz (1) in excellent chemical and optical purity. A novel, enantioselective addition of Li-cyclopropyl acetylide (4a) to p-methoxybenzyl-protected ketoaniline 3a mediated by (1R,2S)-N-pyrrolidinylnorephedrine lithium alkoxide (5a) establishes the stereogenic center in the target with a remarkable level of stereocontrol.