214353-17-0

Usage

Uses

Used in Pharmaceutical Industry:
2'-Amino-5'-chloro-2,2,2-trifluoroacetophenone serves as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and functional groups make it a valuable building block for the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2'-Amino-5'-chloro-2,2,2-trifluoroacetophenone is utilized as an intermediate for the production of agrochemicals, such as pesticides and herbicides. Its chemical properties contribute to the effectiveness of these products in controlling pests and promoting crop growth.
Used in Organic Synthesis:
2'-Amino-5'-chloro-2,2,2-trifluoroacetophenone is employed as a versatile building block in the synthesis of complex organic molecules. Its unique structure allows for various chemical reactions, enabling the creation of a wide range of organic compounds with diverse applications.
Used in Medicinal Chemistry:
2'-Amino-5'-chloro-2,2,2-trifluoroacetophenone has been studied for its potential use in medicinal chemistry, particularly for its antibacterial and antifungal properties. Its ability to inhibit the growth of harmful microorganisms makes it a promising candidate for the development of new antimicrobial agents.

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 65854-91-3 N-(4-chlorophenyl)-2,2-dimethylpropionamide 
• 106-47-8 4-chloro-aniline 
• 181190-33-0 N-(4-chloro-2-(2,2,2-trifluoroacetyl)phenyl)pivalamide 
• 354-32-5 trifluoracetyl chloride 
• 29551-81-3 N-chloro-N-(2-chlorophenyl)acetamide 
• 533-17-5 N-(2-chlorophenyl)acetamide 
• 1150561-03-7 N-[2-(trifluoroacetyl)phenyl]-2,2-dimethylpropionamide 
• 62662-74-2 N-(2-chlorophenyl)-2,2,2-trimethylacetamide 
• 95-51-2 o-chloroaniline 
• 430458-62-1 N-(2-bromophenyl)isobutyramide 
• 6625-74-7 N-pivaloylaniline 
• 62-53-3 aniline 

Downstream Products

• 209460-09-3 1-[5-chloro-2-(tritylamino)phenyl]-2,2,2-trifluoroethan-1-one 

Relevant academic research and scientific papers

Practical asymmetric synthesis of Efavirenz (DMP 266), an HIV-1 reverse transcriptase inhibitor

A highly enantioselective and practical synthesis of the HIV-1 reverse transcriptase inhibitor efavirenz (1) is described. The synthesis proceeds in 62% overall yield in seven steps from 4-chloroaniline (6) to give efavirenz (1) in excellent chemical and optical purity. A novel, enantioselective addition of Li-cyclopropyl acetylide (4a) to p-methoxybenzyl-protected ketoaniline 3a mediated by (1R,2S)-N-pyrrolidinylnorephedrine lithium alkoxide (5a) establishes the stereogenic center in the target with a remarkable level of stereocontrol.

Synthesis method of 4-chloro-2-trifluoroacetylaniline hydrochloride hydrate

The invention provides a synthesis method of a 4-chloro-2-trifluoroacetylaniline hydrochloride hydrate. The synthesis method comprises the following steps of dissolving o-halogenated aniline in an organic solvent, then adding alkali, then adding an acylating agent, and carrying out an acylation reaction between the o-halogenated aniline and the acylating agent under an alkaline condition to obtaina compound I; carrying out a chlorination reaction between the compound I and a chlorinating agent under a weakly alkaline condition to obtain a compound II; adopting the compound II and magnesium for a reaction in an environment of inert gas to obtain a Grignard reagent intermediate, and carrying out a reaction between the Grignard reagent intermediate and a trifluoroacetic acid derivative to obtain a compound III; carrying out a reaction between the compound III and concentrated hydrochloric acid to obtain the 4-chloro-2-trifluoroacetylaniline hydrochloride hydrate. According to the synthesis method, the reaction condition is mild, the adopted raw materials are easy to obtain, the price is low, the total yield of the prepared target product can reach 80.35%, the purity can reach 99.8%,and the synthesis method is suitable for industrial production.

A preparing method of an efavirenz intermediate

The invention provides a preparing method of an efavirenz intermediate, and relates to the technical field of compound preparation methods. The method includes performing amino protection on 2-halogenaniline (II), as a raw material, with acyl chloride; reacting the generated N-acyl-2-halogen-aniline (III) with metal magnesium to generate a Grignard reagent; then reacting the Grignard reagent witha trifluoroacetyl amine compound (IV) to obtain N-acyl-2-(trifluoroacetyl)aniline (V); then reacting the N-acyl-2-(trifluoroacetyl)aniline (V) with chlorine under the function of a catalyst to obtainN-acyl-4-chloro-2-(trifluoroacetyl)aniline (VI); and performing hydrolysis and salting to obtain 4-chloro-2-(trifluoroacetyl)aniline hydrochloride hydrate (I). The method has characteristics of shortsynthetic steps, simple operation, high safety, a large raw material choosing range, and a high yield of the target product, and is suitable for large-scale industrial production.

Method for synthesizing 4-chloro-2-(trifluoroacetyl)aniline hydrochloride hydrate

The invention relates to a method for synthesizing an efavirenz intermediate, in particular to a method for synthesizing a 4-chloro-2-(trifluoroacetyl)aniline hydrochloride hydrate. The method includes the following steps that an acylating agent is added to aniline in an organic solvent, aniline is subjected to an acylation reaction under the alkaline condition and at the temperature of 5-15 DEG C to obtain a compound A, the compound A reacts with a chlorinating agent under the alkalescent condition to obtain a compound B, the compound B reacts with trifluoroacetic acid ethyl ester under the action of butyl lithium to obtain a compound C, the compound C and hydrochloric acid are subjected to a reflux reaction at 60-65 DEG C, and the 4-chloro-2-(trifluoroacetyl)aniline hydrochloride hydrate is obtained. Reaction conditions are mild, energy consumption is greatly reduced, raw materials in use are easy to obtain, cost is low, and pollution is little. The method is easy to operate, the total yield can reach 77.2%, the purity can reach 99% or above, product quality is good, and the method is suitable for industrial production.

Preparation method of 4-chloro-2-(trifluoroacetyl) aniline hydrochloride hydrate

The invention discloses a preparation method of a 4-chloro-2-(trifluoroacetyl) aniline hydrochloride hydrate and belongs to the field of compound synthesis. The method adopts parachloroaniline as a raw material and comprises steps as follows: 1, parachlor

Method for preparing 4-chlorine-2-(trifluoroacetyl) aniline hydrochloride hydrate

The invention discloses a method for preparing a 4-chlorine-2-(trifluoroacetyl) aniline hydrochloride hydrate, and belongs to the field of compound synthesis. P-chloroaniline serves as a raw material, the method includes the following steps that 1, the p-chloroaniline and acid anhydride are reacted to obtain 4-chlorine-N-phthaloyl aniline; 2, the 4-chlorine-N-phthaloyl aniline and trifluoroacetic acid ethyl ester are reacted under the effect of butyl lithium to obtain N-(4-chlorine-2 trifluoroacetyl phenyl)-phthalic diamide; 3, after the N-(4-chlorine-2 trifluoroacetyl phenyl)-phthalic diamide and hydrazine hydrate are heated and subjected to reflux in absolute ethyl alcohol, hydrochloric acid and glacial acetic acid are added, and the 4-chlorine-2-(trifluoroacetyl) aniline hydrochloride hydrate is obtained. The method is easy to operate, low in cost and suitable for industrial production, and the total yield is up to 82.2%.