20949-67-1

Upstream product

• 141-84-4 2-thioxo-4-thiazolidinone 
• 100-39-0 benzyl bromide 
• 79-04-9 chloroacetyl chloride 
• 54895-19-1 benzyl dithiocarbamate 

Downstream Products

• 1433721-17-5 (5S,6S,10S)-2-(benzylthio)-6,10-di(furan-2-yl)-4-oxo-1-thia-3-azaspiro[4.5]deca-2,7-diene-7-carboxaldehyde 
• 1433721-23-3 (5S,6R,10R)-2-(benzylthio)-6,10-diprop-1-yl-4-oxo-1-thia-3-azaspiro[4.5]deca-2,7-diene-7-carboxaldehyde 
• 1433721-49-3 (3S,4aS,5′S,6S,8S)-diethyl 2′-(benzylthio)-3-ethoxy-4′-oxo-3,4,4a,5,6,8-hexahydro-4′H-spiro[isochromene-7,5′-thiazole]-6,8-dicarboxylate 
• 1433721-19-7 (5S,6S,10S)-diethyl 2-(benzylthio)-7-formyl-4-oxo-1-thia-3-azaspiro[4.5]deca-2,7-diene-6,10-dicarboxylate 
• 1433721-21-1 (5S,6R,10R)-2-(benzylthio)-6,10-dimethyl-4-oxo-1-thia-3-azaspiro[4.5]deca-2,7-diene-7-carboxaldehyde 
• 1433721-07-3 (5S,6R,10S)-2-(benzylthio)-4-oxo-6,10-diphenyl-1-thia-3-azaspiro[4.5]deca-2,7-diene-7-carboxaldehyde 

Relevant academic research and scientific papers

Dithiocarbamate as an efficient intermediate for the synthesis of 2-(alkylthio)thiazol-4(5H)-ones

An effective approach for the synthesis of 2-(alkylthio)thiazol-4(5H)-ones from alkyl dithiocarbamates and chloroacetyl chloride in the presence of NaHCO3 has been developed. Good to excellent yields of products, simple reaction conditions and

Traceless solid-phase synthesis of 2-amino-5-alkylidene-thiazol-4-ones

2-Amino-5-alkylidene-thiazol-4-ones bearing two diversity points are prepared by a solid-phase strategy exploiting rhodanine as the starting material. Rhodanine is first loaded on bromo-Wang resin, subjected to Knovenagel condensation with aldehydes, and cleaved off the resin in a traceless manner by means of an amine.