20951-13-7

Upstream product

• 67-56-1 methanol 
• 66640-63-9 2,5-dichlorophenyl methyl sulfone 
• 124-41-4 sodium methylate 
• 22952-33-6 5-chloro-2-methoxybenzenesulfonohydrazide 
• 868-85-9 Dimethyl phosphite 
• 77-78-1 dimethyl sulfate 
• 23385-57-1 4-Chlor-2-methylmercapto-1-methoxy-benzol 
• 744154-58-3 5-chloro-2-methoxy-benzenesulfinic acid 

Downstream Products

• 20951-16-0 (4-Chloro-2-methanesulfonyl-phenoxy)-acetic acid ethyl ester 
• 20951-37-5 4-chloro-2-methanesulfonyl-phenol 

Relevant academic research and scientific papers

High Chemoselectivity in the Construction of Aryl Methyl Sulfones via an Unexpected C-S Bond Formation between Sulfonylhydrazides and Dimethyl Phosphite

A highly chemoselective route to aryl methyl sulfones via an unexpected C S bond formation between sulfonylhydrazides and dimethyl phosphite catalyzed by NaI under mild conditions has been established. This transformation provides an alternative and metal-free pathway to acquire various aryl methyl sulfones in good to excellent yields. Notably, dimethyl phosphite was employed as a stable and readily available alkyl source.

CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS

The present invention relates to compounds of formula (I) for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases, including cathepsins B, K, C, F, H, L, O, S, W and X. Of particular interest are diseases associated with Cathepsin K.