20962-71-4

Usage

Chemical compound

2-Acetyl-4-methyl-4-pentenoic acid methyl ester

Also known as

Methyl 3,5-dimethyl-4-pentenoate

Physical properties

Colorless liquid with a fruity odor

Common uses

Flavoring agent in the food and beverage industry, intermediate in pharmaceutical and fragrance production

Synthesis method

Esterification of 3,5-dimethyl-4-pentenoic acid with methanol

Potential allergen

Can cause skin irritation and sensitization

Caution

Handle with care, use in compliance with safety guidelines

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 563-47-3 3-Chloro-2-methylpropene 
• 19737-36-1 diethyl-methallyl-amine 
• 72047-94-0 [2-(acetoxymethyl)prop-2-enyl]trimethylsilane 
• 1458-98-6 2-methyl-3-bromo-1-propene 
• 14568-34-4 2-methylprop-2-ene-1-sulfonyl chloride 

Downstream Products

• 268738-16-5 5-methylhex-5-ene-2,3-dione 3-oxime 

Relevant academic research and scientific papers

Iodine-Catalyzed Synthesis of Substituted Furans and Pyrans: Reaction Scope and Mechanistic Insights

Substituted pyrans and furans are core structures found in a wide variety of natural products and biologically active compounds. Herein, we report a practical and mild catalytic method for the synthesis of substituted pyrans and furans using molecular iodine, a simple and inexpensive catalyst. The method described is performed under solvent-free conditions at an ambient temperature and atmosphere, thus offering a facile and practical alternative to currently available reaction protocols. A combination of experimental studies and density functional theory calculations revealed interesting mechanistic insights into this seemingly simple reaction.

Palladium-catalyzed desulfinylative C-C allylation of Grignard reagents and enolates using allylsulfonyl chlorides and esters

2-Methylprop-2-ene-, prop-2-ene-, 1-methylprop-2-ene-, and (E)-but-2-enesulfonyl chlorides have been used as electrophilic partners in desulfinylative palladium-catalyzed C-C coupling with Grignard reagents and sodium salts of dimethyl malonate and methyl

CALCILYTIC COMPOUNDS

Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.

REACTIONS OF ALLYLIC COMPOUNDS SUCH AS ALLYL ALCOHOLS, ALLYL ETHERS, AND ALLYLAMINES USING trans-Mo(N2)2(Ph2PCH2CH2PPh2)2

Double-bond migration of allylic alcohols and allylic alkyl ethers was catalytically effected with trans-Mo(N2)2(dpe)2(dpe=Ph2PCH2CH2PPh2).Decarbonylation occurred simultaneously in the case of allyl alcohol.Diallyl ether and allyl phenol ether gave the fragmentation products presumably through initial oxidative addition of the allyl-O bond.Allylamine was converted to N-propylideneallylamine and NH3.N,N-Dimethylallylamine was isomerized to N-trans-propenyldimethylamine, which was further transformed into 4-dimethylamino-1,3-hexadiene and dimethylamine on addition of oxygen.The catalytic allylation of methyl acetoacetate with allylic ethers and amines was achieved by use of trans-Mo(N2)2(dpe)2.