20963-49-9Relevant academic research and scientific papers
Enantioselective synthesis of β-substituted chiral allylic amines: Via Rh-catalyzed asymmetric hydrogenation
Wang, Qingli,Gao, Wenchao,Lv, Hui,Zhang, Xumu
, p. 11850 - 11853 (2016/10/07)
An asymmetric mono-hydrogenation of 2-acetamido-1,3-dienes catalyzed by a Rh-DuanPhos complex has been developed. This approach provides easy access to chiral allylic amines with excellent enantioselectivities and high regioselectivities. The products are valuable chiral building blocks for pharmaceuticals.
Rh(III)-catalyzed decarboxylative coupling of acrylic acids with unsaturated oxime esters: Carboxylic acids serve as traceless activators
Neely, Jamie M.,Rovis, Tomislav
supporting information, p. 2735 - 2738 (2014/03/21)
α,β-Unsaturated carboxylic acids undergo Rh(III)-catalyzed decarboxylative coupling with α,β-unsaturated O-pivaloyl oximes to provide substituted pyridines in good yield. The carboxylic acid, which is removed by decarboxylation, serves as a traceless activating group, giving 5-substituted pyridines with very high levels of regioselectivity. Mechanistic studies rule out a picolinic acid intermediate, and an isolable rhodium complex sheds further light on the reaction mechanism.
2-Silyloxy-1,2-oxazines, a New Type of Acetals of Conjugated Nitroso Alkenes
Tishkov, Alexander A.,Lesiv, Alexey V.,Khomutova, Yulya A.,Strelenko, Yury A.,Nesterov, Ivan D.,Antipin, Michael Yu.,Ioffe, Sema L.,Denmark, Scott E.
, p. 9477 - 9480 (2007/10/03)
3-Alkyl-substituted 1,2-oxazine N-oxides 2 can be selectively transformed into 2-silyloxy-1,2-oxazines 1 upon treatment with silylating reagents. In the solid state derivatives 1 adopt a chair conformation with the pyramidal nitrogen atom, whereas in solu
