209685-47-2Relevant academic research and scientific papers
Discovery of heteroaryl sulfonamides as new EP1 receptor selective antagonists
Naganawa, Atsushi,Matsui, Toshiaki,Saito, Tetsuji,Ima, Masaki,Tatsumi, Tadashi,Yamamoto, Shingo,Murota, Masayuki,Yamamoto, Hiroshi,Maruyama, Takayuki,Ohuchida, Shuichi,Nakai, Hisao,Kondo, Kigen,Toda, Masaaki
, p. 6628 - 6639 (2007/10/03)
4-({2-[Isobutyl(phenylsulfonyl)amino]-5-(trifluoromethyl)phenoxy}methyl)benzoic acid (1) is a functional PGE2 antagonist selective for EP1 receptor subtype. Analogs of 1, in which the phenyl-sulfonyl moiety has been replaced with more hydrophil
Discovery of new chemical leads for selective EP1 receptor antagonists
Naganawa, Atsushi,Saito, Tetsuji,Nagao, Yuuki,Egashira, Hiromu,Iwahashi, Maki,Kambe, Tohru,Koketsu, Masatoshi,Yamamoto, Hiroshi,Kobayashi, Michiyoshi,Maruyama, Takayuki,Ohuchida, Shuichi,Nakai, Hisao,Kondo, Kigen,Toda, Masaaki
, p. 5562 - 5577 (2007/10/03)
A series of 4-({2-[alkyl(phenylsulfonyl)amino]phenoxy}methyl)benzoic acids were identified as functional PGE2 antagonists with selectivity for the EP1 receptor subtype starting from a chemical lead 1, which was found while screening our in-house compound library. Discovery of the optimized analogs 21-23 is presented here and structure-activity relationships (SAR) are also discussed.
Sulfonamide and carboxamide derivatives and drugs containing the same as the active ingredient
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, (2008/06/13)
The sulfonamide or carboamide derivatives of the formula (I) and a pharmaceutical composition which comprise them as an active ingredient: (wherein A ring, B ring is carbocyclic ring, heterocyclic ring; Z1is —COR1, —CH═CH—COR1/
