20970-69-8Relevant academic research and scientific papers
The multicomponent Hantzsch reaction: Comprehensive mass spectrometry monitoring using charge-tagged reagents
Santos, Vanessa G.,Godoi, Marla N.,Regiani, Thaís,Gama, Fernando H. S.,Coelho, Mirela B.,De Souza, Rodrigo O. M. A.,Eberlin, Marcos N.,Garden, Simon J.
supporting information, p. 12808 - 12816 (2015/03/30)
A novel strategy for the ESI-MS monitoring of reaction solutions involving the alternate use of permanently charge-tagged reagents has been used for comprehensive mass spectrometry monitoring of the multicomponent Hantzsch 1,4-dihydropyridine reaction. By placing a charge tag on either, or both, of the two key reactants, ion suppression effects for ESI were eliminated or minimized, and comprehensive detection of charge-tagged intermediates was achieved. The strategy allowed the trapping and characterization of the important intermediates in the mechanism for 1,4-dihydropyridine formation.
Synthesis of some new unsymmetrically substituted 1,4-dihydropyridines
Memarian, Hamid R.,Abdoli-Senejani, Masumeh,D?pp, Dietrich
, p. 50 - 56 (2008/02/10)
A series of some new 3,5-unsymmetrically substituted 1,4-dihydropyridines have been synthesized, which have ethoxycarbonyl and acetyl groups on 3- and 5-positions, respectively. A three-step procedure has been examined to increase the yield of the desired products, by suppressing the formation of the symmetrically substituted 3,5-diacetyl-1,4-dihydropyridines and 3,5-diethoxycarbonyl-1,4-dihydropyridines.
