20973-90-4

Usage

Physical appearance

Yellow-to-orange liquid

Primary use

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Versatility

Preparation of various biologically active compounds

Biological activities

Anti-inflammatory, anti-bacterial, and anti-fungal properties

Additional applications

Manufacture of dyes and other organic compounds

Toxicity

Toxic if ingested or inhaled

Hazards

May cause skin and eye irritation upon contact

Safety precautions

Proper safety measures should be taken when handling DCAD

Upstream product

• 20973-76-6 2,6-Dichlor-ω-dimethylaminostyrol 
• 2014-83-7 1,3-Dichloro-2-chloromethyl-benzene 
• 68-12-2 N,N-dimethyl-formamide 
• 3215-64-3 2,6-dichlorophenylacetonitrile 
• 118-69-4 2,6-dichlorotoluene 
• 19230-28-5 1,3-dichloro-2-iodobenzene 
• 135879-73-1 [(E)-2-(2,6-Dichloro-phenyl)-vinyl]-carbamic acid methyl ester 
• 30595-79-0 2-(2,6-dichlorophenyl)ethan-1-ol 
• 6575-24-2 2-(2,6-dichlorophenyl)acetic acid 
• 85995-36-4 (E)-3-(2,6-dichlorophenyl)acrylamide 

Downstream Products

• 257864-12-3 2,6-dichlorophenylacetaldehyde dimethylacetal 
• 1580465-97-9 N¹-(2,6-dichlorophenethyl)-N³,N³-dimethylpropane-1,3-diamine 
• 1160608-90-1 6-Chloro-8-(2,6-dichloro-benzyl)-9H-purine 
• 1159097-28-5 (2,6-dichlorophenyl)acetaldehyde oxime 
• 46398-59-8 β-(2,6-Dichlorphenyl)-ethylidenaminoguanidin 

Relevant academic research and scientific papers

Regioselective, Diastereoselective, and Enantioselective One-Pot Tandem Reaction Based on an in Situ Formed Reductant: Preparation of 2,3-Disubstituted 1,5-Benzodiazepine

The 1,5-benzodiazepines are important skeletons frequently contained in medicinal chemistry. Herein, we described an unexpected tandem cyclization/transfer hydrogenation reaction for obtaining chiral 2,3-disubstituted 1,5-benzodiazepines. The enolizable aryl aldehydes were chosen as substrates to react with symmetric and unsymmetric o-phenylenediamines. The unforeseen tandem reaction occurred among many possible latent side reactions under chiral phosphoric acid catalysis and affords the corresponding products in moderate yields and regioselectivities, good diastereoselectivities, and enantiomeric ratio (up to 99:1).

THERAPEUTIC COMPOUNDS

The invention provides compounds of formula Ia′, Ib′, Ic′, and Id′: and pharmaceutically acceptable salts thereof, wherein the variables A, R6, R7, R8, R9, Rx, L, X, Y, and Z have the meaning as described herein. The compounds are useful for reducing endoplasmic reticulum stress and for producing analgesia in an animal.

Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1

Certain TRPV1-modulating imidazolo-, oxazolo-, and thiazolopyrimdine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPV1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease.

Nitrogen-heterocyclic compound and process for production thereof

A nitrogen-heterocyclic compound is provided which is represented by General Formula (1): where R1and R2are independently hydrogen, an alkyl group, an aryl group, or a heteroaryl group; R3is hydrogen or an aryl group; Rsu

Palladium/P(t-Bu)3-catalyzed synthesis of aryl t-butyl ethers and application to the first synthesis of 4-chlorobenzofuran

Pd/P(t-Bu)3 catalyzed reaction of aryl halides with sodium t-butoxide effectively to give aryl t-butyl ethers. The high catalytic activity realized the formation of aryl t-butyl ethers from not only electron-deficient aryl halides but also electron-rich aryl halides. Moreover, the first synthesis of 4-chlorobenzofuran was attained utilizing the selective mono-t-butoxylation of aryl dihalide.

A facile approach to arylacetaldehydes via polymeric palladium catalyst

Several arylacetaldehydes 5 were synthesized in moderate yields via Heck reaction of acrylamide (1) with substituted iodobenzenes 2 in the presence of the polymeric catalyst (P)-phenyl-(1,10-phenanthroline)-palladium(0) [(P)-ph-phen·Pd(0)] followed by Hofmann reaction and subsequent hydrolysis.