20973-90-4

Basic information

• Product Name: 2-(2,6-DICHLOROPHENYL)ACETALDEHYDE
• Synonyms: 2-(2,6-DICHLOROPHENYL)ACETALDEHYDE;2,6-dichlorobenzeneacetaldehyde;Benzeneacetaldehyde, 2,6-dichloro-
• CAS NO: 20973-90-4
• Molecular Formula: C₈H₆Cl₂O
• Molecular Weight: 189.03864
• Mol File: 20973-90-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 269.4±25.0 °C(Predicted)
• Appearance: /
• Density: 1.317±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(2,6-DICHLOROPHENYL)ACETALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,6-DICHLOROPHENYL)ACETALDEHYDE(20973-90-4)
• EPA Substance Registry System: 2-(2,6-DICHLOROPHENYL)ACETALDEHYDE(20973-90-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Hazardous Substances Data: 20973-90-4(Hazardous Substances Data)

Usage

Physical appearance

Yellow-to-orange liquid

Primary use

Intermediate in the synthesis of pharmaceuticals and agrochemicals

Versatility

Preparation of various biologically active compounds

Biological activities

Anti-inflammatory, anti-bacterial, and anti-fungal properties

Additional applications

Manufacture of dyes and other organic compounds

Toxicity

Toxic if ingested or inhaled

Hazards

May cause skin and eye irritation upon contact

Safety precautions

Proper safety measures should be taken when handling DCAD

Upstream product

• 2014-83-7 1,3-Dichloro-2-chloromethyl-benzene 
• 68-12-2 N,N-dimethyl-formamide 
• 3215-64-3 2,6-dichlorophenylacetonitrile 
• 118-69-4 2,6-dichlorotoluene 
• 6575-24-2 2-(2,6-dichlorophenyl)acetic acid 
• 85995-36-4 (E)-3-(2,6-dichlorophenyl)acrylamide 
• 19230-28-5 1,3-dichloro-2-iodobenzene 
• 135879-73-1 [(E)-2-(2,6-Dichloro-phenyl)-vinyl]-carbamic acid methyl ester 
• 20973-76-6 2,6-Dichlor-ω-dimethylaminostyrol 
• 30595-79-0 2-(2,6-dichlorophenyl)ethan-1-ol 

Downstream Products

• 257864-12-3 2,6-dichlorophenylacetaldehyde dimethylacetal 
• 1580465-97-9 N¹-(2,6-dichlorophenethyl)-N³,N³-dimethylpropane-1,3-diamine 
• 1160608-90-1 6-Chloro-8-(2,6-dichloro-benzyl)-9H-purine 
• 1159097-28-5 (2,6-dichlorophenyl)acetaldehyde oxime 
• 46398-59-8 β-(2,6-Dichlorphenyl)-ethylidenaminoguanidin 

Relevant articles and documents

Regioselective, Diastereoselective, and Enantioselective One-Pot Tandem Reaction Based on an in Situ Formed Reductant: Preparation of 2,3-Disubstituted 1,5-Benzodiazepine

The 1,5-benzodiazepines are important skeletons frequently contained in medicinal chemistry. Herein, we described an unexpected tandem cyclization/transfer hydrogenation reaction for obtaining chiral 2,3-disubstituted 1,5-benzodiazepines. The enolizable aryl aldehydes were chosen as substrates to react with symmetric and unsymmetric o-phenylenediamines. The unforeseen tandem reaction occurred among many possible latent side reactions under chiral phosphoric acid catalysis and affords the corresponding products in moderate yields and regioselectivities, good diastereoselectivities, and enantiomeric ratio (up to 99:1).

Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1

Certain TRPV1-modulating imidazolo-, oxazolo-, and thiazolopyrimdine compounds are described. The compounds may be used in pharmaceutical compositions and methods for treating disease states, disorders, and conditions mediated by TRPV1 activity, such as pain, arthritis, itch, cough, asthma, or inflammatory bowel disease.

Palladium/P(t-Bu)3-catalyzed synthesis of aryl t-butyl ethers and application to the first synthesis of 4-chlorobenzofuran

Pd/P(t-Bu)3 catalyzed reaction of aryl halides with sodium t-butoxide effectively to give aryl t-butyl ethers. The high catalytic activity realized the formation of aryl t-butyl ethers from not only electron-deficient aryl halides but also electron-rich aryl halides. Moreover, the first synthesis of 4-chlorobenzofuran was attained utilizing the selective mono-t-butoxylation of aryl dihalide.