30595-79-0

Basic information

• Product Name: 2,6-DICHLOROPHENETHYLALCOHOL
• Synonyms: TIMTEC-BB SBB005836;2,6-DICHLOROPHENETHYLALCOHOL;2-(2,6-DICHLOROPHENYL)ETHANOL;2,6-DICHLOROPHENETHYLALCOHOL 96%;2,6-Dichlorophenethyl alcohol,96%;2,6-Dichlorophenethyl alcohol, 96% 5GR;2,6-Dichlorophenethanol;2,6-Dichlorobenzeneethanol
• CAS NO: 30595-79-0
• Molecular Formula: C₈H₈Cl₂O
• Molecular Weight: 191.05
• Product Categories: Benzhydrols, Benzyl & Special Alcohols
• Mol File: 30595-79-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 59-65 °C
• Boiling Point: 152 °C / 12mmHg
• Flash Point: 117.2 °C
• Appearance: White to slightly yellow/Crystalline Powder, Crystals or Flakes
• Density: 1.2559 (rough estimate)
• Vapor Pressure: 0.00229mmHg at 25°C
• Refractive Index: 1.5670 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 14.56±0.10(Predicted)
• CAS DataBase Reference: 2,6-DICHLOROPHENETHYLALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DICHLOROPHENETHYLALCOHOL(30595-79-0)
• EPA Substance Registry System: 2,6-DICHLOROPHENETHYLALCOHOL(30595-79-0)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 30595-79-0(Hazardous Substances Data)

Usage

Chemical Properties

white to slightly yellow crystalline powder,

InChI:InChI=1/C8H8Cl2O/c9-7-2-1-3-8(10)6(7)4-5-11/h1-3,11H,4-5H2

Upstream product

• 54551-83-6 methyl 2-(2,6-dichlorophenyl)acetate 
• 6575-24-2 2-(2,6-dichlorophenyl)acetic acid 

Downstream Products

• 209256-42-8 2,3-dihydro-1-benzofuran-4-carbaldehyde 
• 609799-22-6 [14C]-Tasimelteon 
• 209257-15-8 1-[(1R,2R)-2-(2,3-dihydro-1-benzofuran-4-yl)cyclopropyl]methanamine 
• 29096-65-9 β-<2,6-Dichlorphenyl>-aethylamino-guanidin 
• 46398-59-8 β-(2,6-Dichlorphenyl)-ethylidenaminoguanidin 
• 230642-84-9 4-ethenyl-2,3-dihydro-1-benzofuran 
• 61698-06-4 3-(2,6-dichlorophenyl)propanenitrile 
• 936946-50-8 2-[2-(2,6-dichloro-phenyl)-ethyl]-thiazole-4-carboxylic acid ethyl ester 
• 871326-60-2 2-[2-(2,6-dichloro-phenyl)-ethyl]-thiazole-4-carboxylic acid 
• 736971-27-0 3-(2,6-dichlorophenyl)propanethioamide 
• 181472-07-1 2-(2,6-dichlorophenyl)-1-iodoethane 
• 118-69-4 2,6-dichlorotoluene 
• 28469-92-3 2,6-dichlorostyrene 
• 289058-20-4 4-chloro-2,3-dihydro-1-benzofuran 

Relevant articles and documents

Imidazo ring PAR4 antagonist and medical applications thereof

The invention relates to an imidazo ring compound represented by formula (I) or formula (II), or a pharmaceutically acceptable salt or ester or solvate thereof. The compound disclosed by the inventioncan be used for preparing medicines for preventing or treating thromboembolic diseases.

Synthesis and biological studies of novel 2-aminoalkylethers as potential antiarrhythmic agents for the conversion of atrial fibrillation

A series of 2-aminoalkylethers prepared as potential antiarrhythmic agents is described. The present compounds are mixed sodium and potassium ion channel blockers and exhibit antiarrhythmic activity in a rat model of ischemia-induced arrhythmias. Structure-activity studies led to the identification of three compounds 5, 18, and 26, which were selected based on their particular in vivo electrophysiological properties, for studies in two canine atrial fibrillation (AF) models. The three compounds converted AF in both models, but only compound 26 was shown to be orally bioavailable. Resolution of the racemate 26 into its corresponding enantiomers 40 and 41 and subsequent biological testing of these enantiomers led to the selection of (1S,2S)-1-(1-naphthalenethoxy)-2-(3- ketopyrrolidinyl)cyclohexane monohydrochloride (41) as a potential atrial selective antiarrhythmic candidate for further development.

AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF

Aminocyclohexyl ether compounds of formula (I), or a solvate or pharmaceutically acceptable salt thereof: are disclosed. In said formula, A, X and R, -R5 have the meanings given in the description. The compounds of the present invention may be inco