209846-33-3Relevant academic research and scientific papers
ALPHA-CINNAMIDE COMPOUNDS AND COMPOSITIONS AS HDAC8 INHIBITORS
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Paragraph 0868; 0869, (2016/10/04)
The present invention relates to inhibitors of histone deacetylases, in particular HDAC8, that are useful for the treatment of cancer and other diseases and disorders, as well as the synthesis and applications of said inhibitors.
A facile and mild approach for stereoselective synthesis of α-fluoro-α,β-unsaturated esters from α-fluoro-β-keto esters via deacylation
Qian, Jinlong,Yi, Wenbin,Lv, Meifang,Cai, Chun
, p. 127 - 132 (2015/02/02)
The highly stereoselective olefination reaction of α-fluoro-β-keto esters for the synthesis of α-fluoro-α,β-unsaturated esters has been developed. The olefination combines nucleophilic addition, intramolecular nucleophilic addition, and elimination in one step, as well as provides a facile synthetic approach to α-fluoro-α,β-unsaturated esters which are important units in many biologically active compounds and useful precursors in a variety of functional-group transformations.
Efficient nucleophilic fluoromethylation and subsequent transformation of alkyl and benzyl halides using fluorobis(phenylsulfonyl)methane
Prakash, G. K. Surya,Chacko, Sujith,Vaghoo, Habiba,Shao, Nan,Gurung, Laxman,Mathew, Thomas,Olah, George A.
supporting information; experimental part, p. 1127 - 1130 (2009/07/25)
An efficient methodology for the nucleophilic fluoromethylation of alkyl and benzyl halides using r-fluoro-α-(phenylsulfonyl)methane (1) as a highly versatile reagent is reported. Using benzyl halides, stereospecific one-pot synthesis of α-fluorovinyl com
Microwave-assisted one-pot synthesis of α-fluoro-α,β- unsaturated esters under solvent-free conditions
Ren, Aishan,Yang, Xiongjun,Hong, Jing,Yu, Xiaochun
experimental part, p. 2376 - 2378 (2009/05/27)
A microwave-assisted approach for the synthesis of α-fluoro-α, β-unsaturated esters from ethyl bromofluoroacetate, aldehydes, and triphenylphosphine in the presence of Zn-Cu under solvent-free conditions was achieved. The reaction was accomplished within
