2098466-94-3Relevant academic research and scientific papers
IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES
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, (2017/07/14)
Compounds of formula I or a stereoisomer or pharmaceutically-acceptable salt thereof, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
Identification of imidazo[1,2-: B] pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling
Moslin,Gardner,Santella,Zhang,Duncia,Liu,Lin,Tokarski,Strnad,Pedicord,Chen,Blat,Zupa-Fernandez,Cheng,Sun,Chaudhry,Huang,D'Arienzo,Sack,Muckelbauer,Chang,Tredup,Xie,Aranibar,Burke,Carter,Weinstein
, p. 700 - 712 (2017/04/27)
As a member of the Janus (JAK) family of non-receptor tyrosine kinases, TYK2 mediates the signaling of pro-inflammatory cytokines including IL-12, IL-23 and type 1 interferon (IFN), and therefore represents an attractive potential target for treating the
