20985-27-7

Upstream product

• 60-12-8 2-phenylethanol 
• 140-29-4 phenylacetonitrile 

Downstream Products

• 2901-34-0 2,4-diphenylbutanoic acid 
• 21460-77-5 2,4-diphenyl-butyryl chloride 
• 7498-87-5 2-phenyl-3,4-dihydro-2H-naphthalen-1-one 

Relevant academic research and scientific papers

Method for synthesizing aromatic acetamide

The preparation method comprises the following steps: dissolving a compound 1 and a compound 2 in an organic solvent, adding a catalyst, a ligand and an alkaline substance, reacting for 2-10 hours at the temperature of 80-160 DEG C in a protective atmosphere, and post-treating the obtained reaction liquid to obtain a compound 3. According to the method, aryl acetamide is synthesized by using alcohol and aryl acetonitrile in one step, so that not only is the use of a toxic alkylating reagent avoided, but also the amide synthesis step is reduced, and the cost is saved; and no by-product is generated in the reaction process, so that the atom utilization rate reaches 100%, and the development requirement of green chemistry is met.

Base-controlled chemoselectivity: direct coupling of alcohols and acetonitriles to synthesise α-alkylated arylacetonitriles or acetamides

We achieved chemoselective synthesis of α-alkylated arylacetonitriles and acetamides by combining Ir complex-catalysed direct coupling of alcohols and nitriles by a simple adjustment of the base. Methanol and ethanol performed well as the alkylating reagents. This method of acetonitrile alkylation provided a novel approach for carbon chain extension.