21460-77-5

Upstream product

• 2901-34-0 2,4-diphenylbutanoic acid 
• 5558-42-9 rac-2,4-diphenylbutyronitrile 
• 103-63-9 1-phenyl-2-bromoethane 
• 140-29-4 phenylacetonitrile 
• 60-12-8 2-phenylethanol 
• 20985-27-7 2,4-diphenylbutanamide 

Downstream Products

• 7498-87-5 2-phenyl-3,4-dihydro-2H-naphthalen-1-one 
• 111027-00-0 7-bromo-3-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 
• 20495-17-4 2-phenyl-1-tetralone oxime 
• 3300-62-7 3-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 
• 28717-84-2 7-chloro-3-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 

Relevant academic research and scientific papers

Base-controlled chemoselectivity: direct coupling of alcohols and acetonitriles to synthesise α-alkylated arylacetonitriles or acetamides

We achieved chemoselective synthesis of α-alkylated arylacetonitriles and acetamides by combining Ir complex-catalysed direct coupling of alcohols and nitriles by a simple adjustment of the base. Methanol and ethanol performed well as the alkylating reagents. This method of acetonitrile alkylation provided a novel approach for carbon chain extension.

A novel class of potential central nervous system agents. 3-Phenyl-2-(1-piperazinyl)-5H-1-benzazepines

A series of 3-phenyl-2-piperazinyl-5H-1-benzazepines and related compounds were synthesized and evaluated for potential neuroleptic activity. The preparation of these compounds was carried out by 2,3-dichlorination of 3-phenyl-2,3,4,5-tetrahydro-1H-1-benz