209850-75-9

Upstream product

• 485394-08-9 2-Amino-N-((S)-1-chloromethyl-2-phenyl-ethyl)-benzamide 
• 118-48-9 isatoic anhydride 
• 3182-95-4 L-Phenylalaninol 
• 208175-33-1 N-[(1S)-1-benzyl-2-hydroxyethyl]-2-aminobenzamide 
• 1885-29-6 anthranilic acid nitrile 
• 615-43-0 2-iodophenylamine 
• 75866-71-6 (4S)-4-benzyl-4,5-dihydro-1,3-oxazole 

Downstream Products

• 1013926-21-0 {2-[(4S)-4-benzyl-4,5-dihydrooxazol-2-yl]phenyl}(thiophene-2-carbonitrile)amine 
• 1157955-07-1 N-{2-[(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl]phenyl}pyridin-2-amine 
• 1157955-36-6 N₂-{2-[(4S)-4-tert-butyl-4,5-dihydro-1,3-oxazol-2-yl]phenyl}-N₆-(2-[(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl]phenyl)-pyridin-2,6-diamine 
• 1195945-80-2 2-[(S)-4-benzyl-4,5-dihydrooxazol-2-yl]-N-{2-[(S)-4-tert-butyl-4,5-dihydrothiazol-2-yl]phenyl}benzenamine 
• 1345265-69-1 2-[(4S)-4-benzyl-4,5-dihydro-1,3-oxazol-2-yl]anilino-3,5-bis(trifluoromethyl)anilinomethanethione 
• 1361926-96-6 2-[(S)-4-benzyl-4,5-dihydrooxazol-2-yl]-N-{2-[(S)-4-isopropyl-4,5-dihydrothiazol-2-yl]phenyl}benzenamine 
• 1361927-01-6 2-[(S)-4-benzyl-4,5-dihydrooxazol-2-yl]-N-{2-[(S)-4-phenyl-4,5-dihydrothiazol-2-yl]phenyl}benzenamine 

Relevant academic research and scientific papers

Absolute control of helicity at the C-termini in quinoline oligoamide foldamers by chiral oxazolylaniline moieties

Absolute one-handed chiral quinoline tetramers andoctamers containing different oxazolylanilines at the C-terminus have been synthesized. The absolute one-handed sense and diastereomeric excess values were valued by 1H NMR. X-ray crystal diffra

Copper-Mediated Diastereoselective C-H Thiolation of Ferrocenes

The first copper-mediated diastereoselective C-H thiolation of ferrocenes has been developed. A chiral oxazoline directing group with tert-butyl substituent is essential to the high diastereoselectivity ratio and the suppression of overreaction of monothi

Oxazolines as Dual-Function Traceless Chromophores and Chiral Auxiliaries: Enantioselective Photoassisted Synthesis of Polyheterocyclic Ketones

2-(o-Amidophenyl)oxa- and -thiazolines undergo excited-state intramolecular proton transfer (ESIPT), generating aza-o-xylylenes capable of intramolecular [4+2] and [4+4] cycloadditions with tethered unsaturated pendants. Facile hydrolysis of the primary p

Palladium-Catalyzed C-2 C-H Heteroarylation of Chiral Oxazolines: Diverse Synthesis of Chiral Oxazoline Ligands

A direct, efficient, and practical protocol to install a chiral oxazoline unit onto aryl/heteroaryl rings via palladium-catalyzed C-H functionalization of 2-positions of oxazolines with a variety of halides using dppe as the ligand has been developed. Var

Cooperative thiourea-Bronsted acid organocatalysis: Enantioselective cyanosilylation of aldehydes with TMSCN

We report a new thiourea - Bronsted acid cooperative catalytic system for the enantioselective cyanosilylation of aldehydes with yields up to 90% and enantioselectivities up to 88%. The addition of an achiral acid was found to be crucial for high asymmetric induction. Mechanistic investigations using a combination of NMR, ESI-MS, and density functional theory computations (including solvent corrections) at the M06/6-31G(d,p) level of theory suggest that the key catalytic species results from the cooperative interaction of bifunctional thioureas and an achiral acid that form well-defined chiral hydrogen-bonding environments.

Chiral primary amine catalyzed asymmetric epoxidation of α-substituted acroleins

1,1-Disubstituted terminal alkenes remain challenging substrates in asymmetric epoxidation reactions. In this study, chiral primary amines are shown to catalyze the asymmetric epoxidation of α-substituted acroleins, a versatile type of 1,1-disubstituted t

The synthesis of new oxazoline-containing bifunctional catalysts and their application in the addition of diethylzinc to aldehydes

The straightforward preparation of new modular oxazoline-containing bifunctional catalysts is reported employing a microwave-assisted Buchwald-Hartwig aryl amination as the key step. Covalent attachment of 2-(o-aminophenyl)oxazolines and pyridine derivati

New thiazoline-oxazoline ligands and their application in the asymmetric friedel-crafts reaction

Six members of a novel non-C2-symmetric ligand class incorporating an oxazoline and. thiazoline unit have been prepared in a four-step, high-yielding and. convergent: synthesis, in which the key step is a microwave-assisted palladium-catalyzed

Synthesis of non-symmetric bis(oxazoline)-containing ligands and their application in the catalytic enantioselective Nozaki-Hiyama-Kishi allylation of benzaldehyde

We report the good to high-yielding three-step synthesis of non-symmetrical bis(oxazoline)-containing ligands possessing an N-thienylaniline unit. The convergent synthesis employed a palladium-catalysed aryl amination of 2-(2′-bromothiophene)nitrile as th

Coupling of bulky, electron-deficient partners in aryl amination in the preparation of tridentate bis(oxazoline) ligands for asymmetric catalysis

A new class of tridentate bis(oxazoline) ligands 7, in which an N-phenylaniline unit links the two oxazoline rings, has been prepared. The key step in their synthesis is a Hartwig-Buchwald type Pd-catalyzed aryl amination between the two bulky o-substituted coupling partners, 2-(2′-bromophenyl)oxazolines 8 and 2-(o-aminophenyl)oxazolines 9. By varying the substituent on the coupling partners, a range of 10 ligands has been prepared in good yield. During the synthesis of 2-(o-aminophenyl)oxazolines 9a-d, a number of products of unexpected side reactions were isolated in two of the three steps. Alternatively, the required 2-(o-aminophenyl)oxazolines 9 were obtained by a DAST-promoted cyclodehydration of hydroxyamides 12a-d without formation of any byproducts.