209861-00-7

Basic information

• Product Name: TF-BF
• Synonyms: TF-BF;2H-Cyclopenta[b]furan-2-one, 5-(benzoyloxy)-4-[(1E)-3,3-difluoro-4-phenoxy-1-butenyl]hexahydro-, (3aR,4R,5R,6aS)-;(3AR,4R,5R,6aS)-4-((E)-3,3-Difluoro-4-phenoxybut-1-en-1-yl)-2-oxohexahydro-2H-cyclopenta[b]furan-;(3AR,4R,5R,6aS)-4-((E)-3,3-Difluoro-4-phenoxybut-1-en-1-yl)-2-oxohexahydro-2H-cy;2H-Cyclopenta[b]furan-2-one, 5-(benzoyloxy)-4-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]hexahydro-, (3aR,4R,5R,6aS)-;(3aR,4R,5R,6aS)-5-(benzoyloxy)-4-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]hexahydro-2H-Cyclopenta[b]furan-2-one;(3aR,4R,5R,6aS)-5-(Benzoyloxy)-4-[(1E)-3,3-difluoro-4-phenoxy-1-butenyl]hexahydro-2H-cyclopenta[b]furan-2-one;(3aR,4R,5R,6aS)-5-(benzoyloxy)-4-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]hexahydro-2H-Cyclopenta[b]furan-2-on
• CAS NO: 209861-00-7
• Molecular Formula: C₂₄H₂₂F₂O₅
• Molecular Weight: 428.4252864
• Mol File: 209861-00-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 588.3±50.0 °C(Predicted)
• Appearance: /
• Density: 1.31±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: TF-BF(CAS DataBase Reference)
• NIST Chemistry Reference: TF-BF(209861-00-7)
• EPA Substance Registry System: TF-BF(209861-00-7)

Safety Data

• Hazardous Substances Data: 209861-00-7(Hazardous Substances Data)

Usage

General Description

TF-BF is a chemical compound that consists of a mixture of tetrahydrofuran (TF) and 1-butanol (BF). Tetrahydrofuran is a clear, colorless, organic solvent with a faint, ether-like odor, commonly used as a reaction solvent in polymerization and pharmaceutical processes. 1-Butanol, on the other hand, is a clear, colorless liquid with a mild, alcohol-like odor, primarily used as a solvent in the production of lacquers, resins, and other coatings. When combined, TF-BF is commonly used as a solvent in various industrial applications, including paint and coating formulation, adhesive production, and chemical synthesis processes in pharmaceutical and polymer industries.

Upstream product

• 237386-02-6 1-bromo-3-phenoxy-propan-2-one 
• 39746-01-5 (1S,5R,6R,7R)-6-formyl-7-benzoyloxy-2-oxabicyclo[3.3.0]octan-3-one 
• 51638-91-6 (3aR,4R,5R,6aS)-2-oxo-4-((E)-3-oxo-4-phenoxybut-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl benzoate 

Downstream Products

• 1449413-13-1 C₂₂H₂₈F₂O₅*C₁₂H₂₃N 
• 209860-87-7 tafluprost 
• 209860-88-8 AFP-172 
• 209861-02-9 (3aR,4R,5R,6aS)-4-((E)-3,3-difluoro-4-phenoxybut-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-2,5-diol 
• 209861-01-8 (3aR,4R,5R,6aS)-4-((E)-3,3-difluoro-4-phenoxybut-1-en-1-yl)-5-hydroxyhexahydro-2H-cyclopenta[b]furan-2-one 

Relevant articles and documents

Preparation method of tafluprost

The invention provides a preparation method of tafluprost. According to the method, a fluorinated raw material is obtained at first, and then, HWE reaction is carried out to form double bonds; and therefore, the double bond addition side reaction during fluorination can be avoided. Therefore, the method disclosed by the invention can be used for obtaining the fluorinated product with high yield and high purity, so that the preparation cost of the tafluprost can be reduced, and the economic benefit of the tafluprost can be improved.

AMINE SALTS OF PROSTAGLANDIN ANALOGS

The present application relates to amine salts of prostaglandin analogs and their uses for the preparation of substantially pure prostaglandin analogs. Specific embodiments relate to amine salts of tafluprost and their uses for the preparation of substant

Synthesis of the highly potent prostanoid FP receptor agonist, AFP-168: A novel 15-deoxy-15,15-difluoroprostaglandin F2α derivative

A novel 15-deoxy-15,15-difluoro-prostaglandin(PG)F2α derivative 6 (AFP-168) has been synthesized from the Corey aldehyde in six steps. A key aspect of this route is difluorination of an enone and a stereoselective Wittig reaction. The compound shows high affinity to the FP receptor and potent activities for an anti-glaucoma agent.