209902-02-3Relevant academic research and scientific papers
Delta agonist hydroxy bioisosteres: The discovery of 3-((1-benzylpiperidin-4-yl){4-[(diethylamino)carbonyl]phenyl}amino)benzamide with improved delta agonist activity and in vitro metabolic stability
Griffin, Andrew M.,Brown, William,Walpole, Christopher,Coupal, Martin,Adam, Lynda,Gosselin, Mylene,Salois, Dominic,Morin, Pierre-Emmanuel,Roumi, Marie
scheme or table, p. 5999 - 6003 (2010/05/18)
We have investigated phenol replacements in a series of diaryl amino piperidine delta opioid agonists. From this study we have demonstrated that the hydroxy functional group can be replaced with a primary amide group, giving enhanced activity at the delta
Compounds with analgesic effect
-
, (2008/06/13)
PCT No. PCT/SE97/02051 Sec. 371 Date Mar. 3, 1998 Sec. 102(e) Date Mar. 3, 1998 PCT Filed Dec. 9, 1997 PCT Pub. No. WO98/28270 PCT Pub. Date Jul. 2, 1998Compounds of general formula (I) wherein m is 0 or 1, and n is 1 or 2; are disclosed and claimed in th
