209958-59-8

Basic information

• Product Name: 1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl) [1,1'-biphenyl]-4-yl]-3-methyl-1H-pyrazole-5-carboxamide
• Synonyms: 1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl) [1,1'-biphenyl]-4-yl]-3-methyl-1H-pyrazole-5-carboxamide
• CAS NO: 209958-59-8
• Molecular Weight: 513.62
• Mol File: 209958-59-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl) [1,1'-biphenyl]-4-yl]-3-methyl-1H-pyrazole-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl) [1,1'-biphenyl]-4-yl]-3-methyl-1H-pyrazole-5-carboxamide(209958-59-8)
• EPA Substance Registry System: 1-(3-cyanophenyl)-N-[2'-(tert-butylaminosulfonyl) [1,1'-biphenyl]-4-yl]-3-methyl-1H-pyrazole-5-carboxamide(209958-59-8)

Safety Data

• Hazardous Substances Data: 209958-59-8(Hazardous Substances Data)

Upstream product

• 2881-99-4 3-cyano-phenylhydrazine hydrochloride 
• 209958-57-6 2-(3-cyano-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester 
• 209958-58-7 1-(3-cyanophenyl)-3-methyl-1H-pyrazol-5-ylcarboxylic acid 
• 82874-96-2 2-methoxyimino-4-oxo-pentaneperoxoic acid ethyl ester 
• 2237-30-1 m-cyanoaniline 
• 17672-26-3 3-cyanophenyl hydrazine 
• 193006-34-7 4-(2'-tert-butylaminosulfonylphenyl)aniline 
• 209917-95-3 1-(3-cyanophenyl)-3-methylpyrazol-5-yl carboxylic acid chloride 

Downstream Products

• 209956-01-4 1-(3-(N-aminoamidino)phenyl)-3-methyl-5-[(2'-tert-butylaminosulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]pyrazole 
• 209960-79-2 1-(3-cyanophenyl)-5-[(2'-aminosulfonyl-[1,1']-biphen-4-yl)aminocarbonyl]-3-methylpyrazole 

Relevant articles and documents

NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS

The present application describes nitrogen containing heteroaromatics and derivatives thereof of formula (I) or pharmaceutically acceptable salt or prodrug forms thereof, wherein J is N or NH and D may be C(=NH)NH2, which are useful as inhibitors of factor Xa.

Discovery of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2′-(methylsulfonyl)-[1,1′-b iphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable inhibitor of blood coagulation factor Xa

Factor Xa (fXa) plays a critical role in the coagulation cascade, serving as the point of convergence of the intrinsic and extrinsic pathways. Together with nonenzymatic cofactor Va and Ca2+ on the phospholipid surface of platelets or endotheli