209983-73-3

Upstream product

• 61071-65-6 (S)-3-phthalimidopiperidin-2-one 
• 771468-60-1 (R)-3-phthalimidopiperidin-2-one 
• 88763-76-2 (R)-(+)-3-Amino-2-piperidinon 
• 16682-12-5 D-ornithine hydrochloride 
• 34294-79-6 (S)-(-)-3-aminopiperidin-2-one 
• 3184-13-2 L-ornithine hydrochloride 

Relevant academic research and scientific papers

Synthesis of bengamide E analogues and their cytotoxic activity

A series of bengamide E analogues were prepared from the corresponding polyketide chain and amino acids via amide coupling reactions. Opening of the polyketide chain lactone ring with α-aminolactams was successfully achieved under microwave irradiation in the presence of sodium 2-ethyl hexanoate. A cytotoxic activity evaluation against a panel of cancer cell lines (KB, HepG-2, Lu-1, MCF-7, HL-60 and Hela) indicated that the 2′R analogues were generally more cytotoxic than the 2′S analogues. Additionally, several analogues exhibited selective inhibition against various cancer cell lines: compounds 32a and 32b selectively inhibited MCF-7 cells, while 33b and 35b were more sensitive toward Lu-1 and HepG-2, respectively. Notably, some of the synthetic analogues possess cytotoxic activities with IC50 values less than 1?μM.

Antibacterial agents

Compounds of formula (I) are antibacterial agents wherein: R3and R4, taken together with the carbon atoms to which they are respectively attached, form an optionally substituted saturated carbocyclic or heterocyclic ring of 5 to 16 a