21003-50-9

Upstream product

• 563-52-0 2-chloro-3-butene 
• 106-42-3 para-xylene 
• 4894-61-5 trans-but-2-enyl chloride 
• 504-61-0 (E)-but-2-enol 
• 598-32-3 2-hydroxy-3-butene 
• 4784-77-4 (E)-1-Bromo-2-butene 
• 106-99-0 buta-1,3-diene 
• 6117-91-5 (E/Z)-2-buten-1-ol 

Downstream Products

• 1074765-29-9 2-(2,3-dibromobutyl)-1,4-dimethylbenzene 
• 1074765-51-7 1-bromo-4-(2,3-dibromobutyl)-2,5-dimethylbenzene 

Relevant academic research and scientific papers

Direct Allylation of Aromatic Compounds with Allylic Chloride using the Supported Reagents System ZnCl2/SiO2-K2CO3/Al2O3

Although the reaction of aromatic compounds with allylic chlorides using ZnCl2/SiO2, gives 2-chloro-1-arylalkanes accompanied with diarylalkanes, similar reaction using ZnCl2/SiO2-K2CO3/Al2O3 produces the monoallylated compound as the major product in good yield.

Hydrogen peroxide-or sodium hypochlorite-induced bromination of 1-arylbut-2-enes

Bromination of 1-arylbut-2-enes in the system [HBr or NaBr (KBr)-HX]-H 2O2 (or NaOCl) under relatively mild conditions leads to electrophilic addition of bromine or hypobromous acid at the side-chain double bond. Under more severe conditions, the process is accompanied by bromination of the aromatic ring. Treatment of the title compounds with peroxy acids (RCOOH-H2O2) gives the corresponding epoxy derivatives which react with HBr and oxygen-containing nucleophiles to produce α-bromo alcohols, diols, and diol acetates.

Intermolecular Friedel-Crafts reaction catalyzed by InCl3

Our recent discovery that In(III) salts were able to activate halides catalytically under mild conditions for the intermolecular Friedel-Crafts cyclization prompted us to explore this highly efficient activation in intermolecular Friedel-Crafts reactions. The alkylation of p-xylene with allylic and benzylic halides was demonstrated under catalytic and mild condition to afford in some cases quantitative yields of the monoalkylated products without the need to employ large excesses of reactants.

Cooperative Friedel-Crafts catalysis in heterobimetallic regime: Alkylation of aromatics by π-activated alcohols

The highly active Friedel-Crafts alkylation (FCA) catalyst, [Ir(COD)Cl(SnCl3)(SnCl4)(arene)]+Cl- (1-SnCl4), is easily generated in one-pot from [Ir(COD)Cl]2 or [Ir(COD)(μ-Cl)Cl(SnCl3)]2 (1) and SnCl4. The reaction of arenes, heteroarenes with benzyl, and allyl alcohols is promoted by 1-SnCl4 (1 mol %) with high turnover frequency. Kinetic evidence is presented to establish FCA pattern. From dual-catalyst combination studies varying the transition metal and main group metal partner, the efficiency of the present catalysts is attributed to the electrophilic "IrIII-SnIV" core. Copyright

An efficient and inexpensive catalyst system for friedel-crafts alkylation of aromatic compounds with benzyl and allyl alcohols

An new strategy that uses Ce2(SO4)3 as an effective catalyst for Friedel-Crafts alkylation of aromatic compounds with benzyl and allyl alcohols is presented. In the presence of 1 to 10 mol% of Ce2(SO4)3, Friedel-Crafts alkylation with both benzyl alcohols, including primary and secondary benzyl alcohols, and allyl alcohol were carried out smoothly and efficiently. Moreover, the catalyst was recovered and reused three times without significant loss of activity.

A new direct allylation of the aromatic compounds with allylic chlorides catalyzed by indium metal

A new method of the direct allylation reaction for the aromatic compounds with allylic chlorides using a catalytic mount of indium in the presence of CaCO3/4A molecular sieves was developed.

Allylation of arenes catalysed by thiolate-bridged diruthenium complexes

In the presence of catalytic amounts of cationic thiolate-bridged diruthenium complexes, arenes react with allylic alcohols to afford the corresponding allylated aromatic products in high yields.

Functional selectivity in Friedel-Crafts alkylations with allylic halides promoted by solid composite lead fluoride reagent

The composite lead fluoride reagent prepared from PbF2 and NaBr is a nonhygroscopic and efficient solid reagent for promoting Friedel-Crafts type reaction of aromatic compounds with allylic halides selectively to afford the monoallylated compounds.