4894-61-5

Basic information

• Product Name: (E)-1-Chlorobut-2-ene
• Synonyms: TRANS-CROTYL CHLORIDE;TRANS-1-CHLORO-2-BUTENE;(E)CROTYL CHLORIDE;CIS,TRANS-CROTYL CHLORIDE;CIS,TRANS-1-CHLORO-2-BUTENE;GAMMA-METHYLALLYL CHLORIDE;2-BUTEN-1-YL CHLORIDE;1-CHLORO-2-BUTYLENE
• CAS NO: 4894-61-5
• Molecular Formula: C₄H₇Cl
• Molecular Weight: 90.55
• EINECS: 209-739-5
• Product Categories: Acyclic;Alkenes;Building Blocks;Chemical Synthesis;Organic Building Blocks
• Mol File: 4894-61-5.mol
• Article Data: 36

Chemical Properties

• Melting Point: -65 °C
• Boiling Point: 85-86 °C(lit.)
• Flash Point: -15 °C
• Appearance: Clear colorless/Liquid
• Density: 0.923 g/mL at 20 °C(lit.)
• Vapor Pressure: 80.6mmHg at 25°C
• Refractive Index: n20/D 1.430
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (E)-1-Chlorobut-2-ene(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-Chlorobut-2-ene(4894-61-5)
• EPA Substance Registry System: (E)-1-Chlorobut-2-ene(4894-61-5)

Safety Data

• Hazard Codes: F,C
• Statements: 11-22-34-36/37
• Safety Statements: 16-26-36/37/39-45-25-27
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 2
• RTECS: EM4264000
• F: 19
• HazardClass: 3.1
• PackingGroup: II
• Hazardous Substances Data: 4894-61-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 4894-61-5 differently. You can refer to the following data:
1. Crotyl Chloride is a useful intermediate used in the preparation of crotyltrichlorosilanes and in other crotylsilylation related reactions
2. Crotyl chloride was used in kinetics measurements of reactions of atomic chlorine with series of unsaturated aldehydes and ketones at 298K. (E)Crotyl chloride was also used in the preparation of (E)-crotyltrichlorosilane.

General Description

Crotyl chloride reacts with trichlorosilane in the presence of tertiary amine and copper salt to give the corresponding allyltrichlorosilane.

InChI:InChI=1/C4H7Cl/c1-2-3-4-5/h2-3H,4H2,1H3/b3-2+

Upstream product

• 504-61-0 (E)-but-2-enol 
• 598-32-3 2-hydroxy-3-butene 
• 4088-60-2 cis-2-buten-1-ol 
• 21890-98-2 (+/-)-chlorocarbonic acid-(1-methyl-allyl ester) 
• 98-95-3 nitrobenzene 
• 108-88-3 toluene 
• 106-98-9 1-butylene 
• 6117-91-5 (E/Z)-2-buten-1-ol 
• 106-99-0 buta-1,3-diene 
• 124-18-5 decane 
• 14661-70-2 (E)-2-buten-1-yl chloroformate 
• 75-09-2 dichloromethane 
• 107-93-7 (E)-but-2-enoic acid 
• 563-52-0 2-chloro-3-butene 

Downstream Products

• 598-32-3 2-hydroxy-3-butene 
• 6117-91-5 (E/Z)-2-buten-1-ol 
• 7688-21-3 cis-2-hexene 
• 4050-45-7 trans-2-hexene 
• 7385-82-2 (E)-5-methyl-2-hexene 
• 4088-54-4 trans-1-methylthio-2-butene 
• 36195-56-9 (E)-but-2-en-1-yl phenyl sulfide 
• 934-10-1 3-phenylbut-1-ene 
• 767-99-7 2-phenylbut-2-ene 
• 504-61-0 (E)-but-2-enol 
• 563-52-0 2-chloro-3-butene 
• 1541-33-9 3-methyl-1,5-hexadiene 
• 1541-23-7 hepta-1,5-diene 
• 61451-89-6 4r-chloromethyl-5t-methyl-3-phenyl-4,5-dihydro-isoxazole 

Relevant articles and documents

N - (4 - alkyl - 5 - benzyl thiazole - 2 - yl) amide and its preparation method and application

The invention relates to N-(4-alkyl-5-benzyl thiazole-2-base) enoyl-amine or salt thereof, shown as a chemical structure formula I, wherein in the formula I, R is selected from C1-C2 alkyl, C3-C4 straight chains or C3-C4 branched alkyl; Y1 and Y3 are selected from hydrogen, methyl, ethyl, hydroxyl, methoxyl, ethoxyl, fluorine, chlorine, bromine or iodine; Y2 and Y4 are selected from hydrogen, methyl and ethyl; n is selected from 1,2,3,4,5,6 or 7; z is selected from hydrogen, methyl or phenyl; salt is selected from hydrochloride, hydrobromide, sulphate, phosphate, mesylate, benzene sulfonate and itramine tosylate. The invention provides the application of the N-(4-alkyl-5-benzyl thiazole-2-base) enoyl-amine or the salt thereof in preparation of anticancer drugs.

α-Selective Allylation of Isatin Imines Using Metallic Barium

The Barbier-type allylation of isatin imines with allylic chlorides was achieved by using metallic barium as the promoter. Various α-allylated 3-amino-2-oxindoles were synthesized from the corresponding allylic chlorides and isatin imines. The double-bond geometry of allylic chlorides was retained throughout the reaction. An arylic bromide or iodide functionality of the products was robust to metalation under the optimum reaction conditions.