21008-79-7 Usage
Uses
Used in Pharmaceutical Industry:
(15aR)-4-(4-Aminobutyl)icosahydropyrido[1,2-e][1,5]diazacycloheptadecin-5-one is used as a pharmaceutical compound for its potential therapeutic applications. Its conversion into isooncinotine through an amide exchange reaction suggests that it may have similar or related pharmacological properties, which could be harnessed for the development of new drugs.
Used in Chemical Research:
In the field of chemical research, (15aR)-4-(4-Aminobutyl)icosahydropyrido[1,2-e][1,5]diazacycloheptadecin-5-one serves as a valuable compound for studying the properties and reactivity of macrocyclic alkaloids. Its structural determination and the possibility of converting it into isooncinotine make it an interesting subject for further investigation and potential applications in the synthesis of novel compounds.
Used in Drug Synthesis:
(15aR)-4-(4-Aminobutyl)icosahydropyrido[1,2-e][1,5]diazacycloheptadecin-5-one can be used as a starting material or intermediate in the synthesis of various drugs, particularly those targeting the central nervous system or other therapeutic areas where macrocyclic alkaloids have demonstrated efficacy. Its unique structure and the ability to undergo amide exchange reactions make it a promising candidate for drug development.
References
Badawietal., Helv. Chirn. Acta, 51, 1813 (1968)
Check Digit Verification of cas no
The CAS Registry Mumber 21008-79-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,1,0,0 and 8 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 21008-79:
(7*2)+(6*1)+(5*0)+(4*0)+(3*8)+(2*7)+(1*9)=67
67 % 10 = 7
So 21008-79-7 is a valid CAS Registry Number.
InChI:InChI=1/C23H45N3O/c24-17-10-12-19-26-21-13-20-25-18-11-9-15-22(25)14-7-5-3-1-2-4-6-8-16-23(26)27/h22H,1-21,24H2/t22-/m1/s1
21008-79-7Relevant academic research and scientific papers
Enantioselective total synthesis of the macrocyclic spermidine alkaloid (-)-oncinotine
Ina, Hiroji,Ito, Masayuki,Kibayashi, Chihiro
, p. 1023 - 1029 (2007/10/03)
The macrocyclic spermidine alkaloid (-)-oncinotine (1), isolated from Oncinotis nitida (Apocynaceae), was synthesized enantioselectively for the first time based on intramolecular iminium ion cyclization utilizing enantiomerically pure (2S)-N-[(benzyloxy)
The chiral total synthesis of (-)-oncinotine
Ina,Ito,Kibayashi
, p. 1015 - 1016 (2007/10/02)
The first chiral synthesis of (-)-oncinotine 1 in natural form has been achieved starting from the protected (S)-N-benzyloxycarbonyl-2-piperidylacetaldehyde 3 based on a new route involving 17-membered ring formation via iminium cyclization, which establi
