21010-34-4Relevant academic research and scientific papers
A metal-free and a solvent-free synthesis of thio-amides and amides: An efficient Friedel-Crafts arylation of isothiocyanates and isocyanates
Varun, Begur Vasanthkumar,Sood, Ankush,Prabhu, Kandikere Ramaiah
, p. 60798 - 60807 (2015/02/19)
A rapid, metal-free and solvent-free (very low loading of solvent in few cases) reaction conditions for synthesizing thioamides and amides using a Bronsted super acid such as triflic acid has been developed. This method shows a broad substrate scope with
Synthesis and analgesic activity in 1,2,4-triazole series
Clemence,Joliveau-Maushart,Meier,et al.
, p. 257 - 266 (2007/10/02)
Derivatives of 1,2,4-triazole have been synthesized. Several methods of synthesis were used and the analgetic and antiinflammatory properties of the products obtained were studied. Structural requirements for analgetic activity were specified. Certain compounds show a high degree of analgetic activity. One of them, RU 39813, has been chosen for extended pharmacological study.
