210169-05-4

Basic information

• Product Name: 3-AMINO-5-FLUOROPYRIDINE
• Synonyms: 3-AMINO-5-FLUOROPYRIDINE;3-Pyridinamine,5-fluoro-(9CI);3-AMINO-5-FLUOROPYRIDINE 97%;5-Fluoropyridin-3-amine;5-Fluoropyridin-3-ylamine;3-Amine-5-fluoro-pyridin;3-AMine-5-fluoro-pyridine;3-PyridinaMine,5-fluoro-
• CAS NO: 210169-05-4
• Molecular Formula: C₅H₅FN₂
• Molecular Weight: 112.11
• EINECS: -0
• Product Categories: PYRIDINE;AMINEPRIMARY;HALIDE;Pyridine series;Pyridines;Boronic Acid;Building Blocks;C5;C5 to C6;Chemical Synthesis;Fluorinated Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles;Fluorine series
• Mol File: 210169-05-4.mol

Chemical Properties

• Melting Point: 86°C
• Boiling Point: 232.7 °C at 760 mmHg
• Flash Point: 94.5 °C
• Appearance: light yellow cryst
• Density: 1.257 g/cm³
• Vapor Pressure: 3.29mmHg at 25°C
• Refractive Index: 1.41
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.74±0.20(Predicted)
• CAS DataBase Reference: 3-AMINO-5-FLUOROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-5-FLUOROPYRIDINE(210169-05-4)
• EPA Substance Registry System: 3-AMINO-5-FLUOROPYRIDINE(210169-05-4)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 26-36-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 210169-05-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-AMINO-5-FLUOROPYRIDINE is used as a key intermediate for the synthesis of Ivosidenib, an isocitrate dehydrogenase-1 (IDH1) inhibitor. Ivosidenib is specifically designed to treat acute myeloid leukemia (AML) and cholangiocarcinoma in adults, offering a targeted approach to managing these conditions.
Used in Organic Synthesis:
3-AMINO-5-FLUOROPYRIDINE is also employed as a reactant in the preparation of nonpeptide inhibitors of measles virus entry. This application highlights its versatility in the development of antiviral agents, contributing to the fight against infectious diseases.

Preparation

synthesis of 3-Amino-5-fluoropyridine: A solution of 3-amino-2,4,6-tribromo-5-fluoropyridine (23c) (0.9 g, 2.6 mmol), triethylamine (1.1 cm3, 7.9 mmol), palladium catalyst (0.1 g of 5% Pd-C catalyst) and DCM (15 cm3) was hydrogenated on a Parr apparatus for 18 h. Water (20 cm3) was added and the mixture filtered and extracted into DCM. The DCM solution was dried (MgS04) and evaporated giving 3-amino-5-fluoropyridine (0.3 g, >95% ), m.p. 86 ·c (from DCM) (Found: C, 53.6; H, 4.6; N, 25.0. C5H5FN2 requires C, 53.6; H, 4.5 N, 25.0%);IR spectrum no. 9; mass spectrum no. 5; nmr spectrum no. 29.

InChI:InChI=1/C8H12F3NO/c1-3-12(4-2)6-5-7(13)8(9,10)11/h5-6H,3-4H2,1-2H3/b6-5-

Upstream product

• 210169-04-3 3-amino-2,4,6-tribromo-5-fluoropyridine 
• 247235-86-5 3-fluoro-5-benzyloxycarbonylaminopyridine 
• 402-66-4 5-fluoropyridine-3-carboxylic acid 
• 700-16-3 Pentafluoropyridine 
• 30841-93-1 2,4,6-tribromo-3,5-difluoropyridine 
• 82671-06-5 2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid 
• 96568-02-4 2,6-dichloro-5-fluoro-3-nicotinoyl chloride 
• 70-58-6 5-fluoropyridine-3-carboxamide 
• 342603-20-7 (5-fluoro-3-pyridinyl)carbamic acid 1,1-dimethylethyl ester 
• 407-20-5 3-bromo-5-fluoropyridine 

Downstream Products

• 823218-51-5 5-fluoro-3-iodo-pyridin-2-amine 
• 478909-64-7 benzyl-(5-fluoro-pyridin-3-yl)-amine 
• 1285515-07-2 5-bromo-N-(5-fluoro-3-pyridinyl)-2-[(phenylmethyl)oxy]benzamide 
• 1285515-17-4 N-(5-fluoro-3-pyridinyl)-2-[(phenylmethyl)oxy]-5-(4-pyridinyl)benzamide 
• 1196091-23-2 (R)-1-[(5-Fluoro-pyridin-3-ylcarbamoyl)-methyl]-3-(1-phenyl-cycloheptanecarbonyloxy)-1-azonia-bicyclo[2.2.2]octane chloride 
• 1338484-90-4 6-bromo-N₁-(5-fluoropyridin-3-yl)benzene-1,2-diamine 
• 1338484-91-5 (S)-tert-butyl 1-(3-bromo-2-(5-fluoropyridin-3-ylamino)phenylamino)-1-oxopropan-2-ylcarbamate 
• 1374969-72-8 tert-butyl (1S,2R)-2-(5-cyano-3-fluoro-6-(5-fluoropyridin-3-ylamino)pyridin-2-ylamino)cyclohexylcarbamate 
• 1393178-59-0 5-fluoro-N-(5-fluoro-2-nitrophenyl)pyridin-3-amine 
• 1393178-60-3 5-fluoro-N₁-(5-fluoropyridin-3-yl)benzene-1,2-diamine 
• 1396084-39-1 4-(2-((5-fluoropyridin-3-yl)amino)-5-((4-(methylsulfonyl)piperazin-1-yl)methyl)pyridin-3-yl)-N,N-bis(4-methoxybenzyl)-6-methyl-1,3,5-triazin-2-amine 
• 1438423-23-4 5-(((1R,2S)-2-aminocyclohexyl)amino)-3-((5-fluoropyridin-3-yl)amino)pyrazine-2-carboxamide 
• 1151802-05-9 7-fluoro-1,5-naphthyridin-4-ol 
• 1437789-80-4 N-((1S,4r)-4-((S)-5,5-dimethyl-2-oxo-4-phenyloxazolidin-3-yl)cyclohexyl)-7-fluoro-1,5-naphthyridine-4-carboxamide 

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