823218-51-5

Basic information

• Product Name: 5-FLUORO-3-IODO-PYRIDIN-2-YLAMINE
• Synonyms: 5-FLUORO-3-IODO-PYRIDIN-2-YLAMINE;2-Amino-3-iodo-5-fluoropyridine;5-Fluoro-3-iodo-2-aMinopyridine;2-PyridinaMine, 5-fluoro-3-iodo-
• CAS NO: 823218-51-5
• Molecular Formula: C₅H₄FIN₂
• Molecular Weight: 238.0015332
• Mol File: 823218-51-5.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 269℃
• Flash Point: 117℃
• Appearance: /
• Density: 2.139
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.22±0.49(Predicted)
• CAS DataBase Reference: 5-FLUORO-3-IODO-PYRIDIN-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUORO-3-IODO-PYRIDIN-2-YLAMINE(823218-51-5)
• EPA Substance Registry System: 5-FLUORO-3-IODO-PYRIDIN-2-YLAMINE(823218-51-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 823218-51-5(Hazardous Substances Data)

Usage

General Description

5-Fluoro-3-iodo-pyridin-2-ylamine is a chemical compound that belongs to the category of organic compounds known as halopyridines, identified by the presence of a halogen atom bonded to a pyridine ring. It has a molecular formula of C5H3FIN3. This chemical's properties of both fluorine and iodine substituents make it an important compound in chemical synthesis and pharmaceutical research due to its potential as a building block for more complex chemical structures. The specific information on its toxicity or safety is not well documented, hence it needs to be handled with general chemical safety protocols.

Upstream product

• 210169-05-4 5-fluoropyridin-3-amine 
• 21717-96-4 2-amino-5-fluoropyridine 
• 823218-50-4 N-(5-fluoro-3-iodo-pyridin-2-yl)-2,2-dimethyl-propionamide 

Downstream Products

• 866318-99-2 5-fluoro-1-tosyl-1H-pyrrolo [2,3-b]pyridine 
• 1417421-99-8 3-bromo-5-fluoro-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 1259279-57-6 5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 936344-74-0 3-ethynyl-5-fluoro-pyridin-2-ylamine 
• 1190309-71-7 3-bromo-5-fluoro-1H-pyrrolo-[2,3-b]pyridine 
• 866319-00-8 5-fluoro-1H-pyrrolo[2,3‐b]pyridine 
• 1211524-51-4 2-amino-3-acetyl-5-fluoropyridine 
• 1187449-15-5 2-cyclopropyl-5-fluoro-1H-pyrrolo[2,3-b]pyridine 

Relevant articles and documents

ANTI-INFLUENZA VIRUS PYRIMIDINE DERIVATIVE

The present invention discloses a class of anti-influenza virus compounds, and the use thereof in the preparation of a drug for treating diseases associated with influenza viruses. In particular, the present invention discloses a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

PYRROLOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF INFLUENZA VIRUS REPLICATION

Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient a safe and effective amount of a compound represented by any of Formulas l-lll, or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a safe and effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

METHODS OF PREPARING INHIBITORS OF INFLUENZA VIRUSES REPLICATION

A method of preparing a compound of Formula (I) or a pharmaceutically acceptable salt thereof comprises: (a) reacting Compound (1) or (b) a pharmaceutically acceptable salt thereof with Compound (2) in the presence of water, an organic solvent, a base, an