210217-82-6Relevant academic research and scientific papers
Synthesis of novel di- and trisaccharide mimetics with non-glycosidic amino bridges
Neumann, Janna,Weingarten, Saskia,Thiem, Joachim
, p. 1130 - 1144 (2008/02/06)
Synthesis of novel di- and trisaccharides using enzymatic glycosylation, Dess-Martin oxidation and reductive animation allows rapid access to the target structures. Thus, a novel class of glycomimetics was obtained having nitrogen inserted as bridging ato
Diastereoselective resolution of 6-substituted glycosides via enzymatic hydrolysis
Grabowska, Urszula,MacManus, David A.,Biggadike, Keith,Bird, Mike I.,Davies, Stephen,Gallagher, Timothy,Hall, Lee D.,Vulfson, Evgeny N.
, p. 351 - 361 (2007/10/03)
The diastereoselectivity of the enzymatic hydrolyses of 4-nitrophenyl 6- deoxy-6-methyl(R)- and (S)-sulfinyl-β-D-galactopyranoside (1a,b), 4- nitrophenyl 7-deoxy-D- and L-glycero-β-D-galacto-heptopyranoside (2a,b) and 4-nitrophenyl 6,7-anhydro-D- and L-glycero-β-Dgalacto-heptopyranoside (3a,b) was investigated using a range of crude glycosidase preparations. It was shown that the enzymes display a high degree of discrimination between diastereomers thereby demonstrating the utility of glycosidases for the diastereomeric resolution of unnatural 6-substituted monosaccharide derivatives.
