210236-01-4Relevant academic research and scientific papers
Efficient synthesis of functionalized furans via ruthenium-catalyzed cyclization of epoxyalkyne derivatives
Lo, Ching-Yu,Guo, Hongyun,Lian, Jian-Jou,Shen, Fwu-Ming,Liu, Rai-Shung
, p. 3930 - 3932 (2007/10/03)
Ruthenium catalyst TpRuPPh3(CH3CN)2Cl is found to effect the cyclization of epoxyalkynes to furans in the presence of Et3N. The reactions worked well for various epoxyalkynes with suitable oxygen and nitrogen functionalities with low loading of catalyst. It failed with disubstituted epoxyalkynes. The mechanism was elucidated by a deuterium labeling experiment that suggested that the mechanism involved a ruthenium-vinylidenium intermediate.
Synthesis of a diterpene taxoid skeleton, bicyclo[9.3.1]pentadecatriene
Shibuya, Satoshi,Isobe, Minoru
, p. 6677 - 6698 (2007/10/03)
The synthesis of bicyclo[9.3.1]pentadecatriene skeleton was investigated by employing cyclization reactions using two key precursors bearing acetylene cobalt complex. Cyclization for the synthesis of strained twelve-membered ring was achieved via Nicholas type reaction in reasonable yield. Reductive decomplexation of the dicobalt hexacarbonyl moiety of the cyclization product was achieved with n-Bu3SnH in the presence of a catalytic amount of NBS in 1,4-cyclohexadiene solvent.
